Evaluation of high-dose regimen of paromomycin against cryptosporidiosis in the dexamethasone-treated rat model
| Autor: | Claude Carbon, Jean-Jacques Pocidalo, C Gaudebout, Louis Garry, J. Polianski, R Verdon, C Marche |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Cecal Infection
Dose medicine.drug_class Paromomycin medicine.medical_treatment Antibiotics Cryptosporidiosis Pharmacology Dexamethasone Rats Sprague-Dawley Feces Mice Medicine Animals Pharmacology (medical) Cryptosporidium parvum Chemotherapy Mice Inbred BALB C biology business.industry biology.organism_classification Anti-Bacterial Agents Rats Regimen Infectious Diseases Immunology Female business Immunosuppressive Agents medicine.drug Research Article |
| Popis: | In the dexamethasone-treated rat model of cryptosporidiosis, paromomycin was effective at a dosage of 50 mg/kg/day or more for ileal infection and 200 mg/kg/day or more for cecal infection. At 1 and 3 weeks after treatment, a persistent infection was demonstrated in all rats. These results confirm the anticryptosporidial activity of paromomycin and underscore the limitations of this compound because of its potential toxicity at such high dosages and its inability to eradicate the infection. |
| Databáze: | OpenAIRE |
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