Proinsulin secretion by a pancreatic beta-cell adenoma. Proinsulin and C-peptide secretion
| Autor: | Arthur H. Rubenstein, Donald F. Steiner, Will G. Ryan, Franco Melani |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Adult
Blood Glucose endocrine system medicine.medical_specialty Pancreatic Beta Cell Adenoma endocrine system diseases Adenoma medicine.medical_treatment Insulin Antibodies Tolbutamide chemistry.chemical_compound Internal medicine Iodine Isotopes Insulin Secretion medicine Humans Insulin Secretion Proinsulin Immunoassay medicine.diagnostic_test C-peptide business.industry Immune Sera General Medicine medicine.disease Adenoma Islet Cell Pancreatic Neoplasms Endocrinology chemistry Injections Intravenous Chromatography Gel Female business Peptides hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The New England journal of medicine. 283(14) |
| ISSN: | 0028-4793 |
| Popis: | In a patient with a pancreatic islet-cell adenoma, fasting serum immunoreactive insulin was 114 to 372 μU per milliliter, about five to 20 times the normal value, but 77 per cent of this "insulin" was found to be proinsulin. After intravenous administration of 1 g of tolbutamide an increase in absolute proinsulin concentration was observed. By means of a specific immunoassay, human C-peptide was detected in the expected elution position after gel filtration of serum extracts. After removal of the adenoma the serum levels of both proinsulin and insulin were very low, and proinsulin represented only 10 per cent of the total immunologic activity. In the tumor tissue, 52 per cent of the total immunologically reactive material was identified as proinsulin. |
| Databáze: | OpenAIRE |
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