Deleterious effect of an anaesthetic on cultured mammalian embryos
| Autor: | C. E. Steele, Matthew H. Kaufman |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Chronic exposure
Time Factors Mammalian Embryos Central nervous system Physiology Early pregnancy factor In Vitro Techniques In vivo medicine Animals Ectogenesis Multidisciplinary Dose-Response Relationship Drug Ethanol biology business.industry Embryo Embryo Mammalian Teratology Culture Media Rats Teratogens medicine.anatomical_structure embryonic structures biology.protein business |
| Zdroj: | Nature. 260:782-784 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/260782a0 |
| Popis: | THE teratogenic effect of certain tranquillisers on human and animal pregnancies has been known for many years1–3. Anaesthetics and other central nervous system depressants may also be teratogenic when given during early pregnancy, possibly because of the inhibitory action of these agents on mitosis4. Anaesthetics can also activate unfertilised mouse eggs in vivo, inducing them to develop parthenogenetically5,6. Chronic exposure to low levels of anaesthetics may result in a significant increase in spontaneous abortions and the birth of children with congenital abnormalities7,8. Experiments with rodents9 which seemed to demonstrate that chronic exposure to anaesthetics could be teratogenic in early pregnancy have proved difficult to repeat10, so that doubt has now been cast on the validity of these earlier results. Attention has also been drawn to the possible risk to the human foetus of surgery carried out during pregnancy11. In the experiments reported here we have demonstrated a direct, deleterious effect on early postimplantation rat embryos in culture of a single exposure to different doses of an anaesthetic. |
| Databáze: | OpenAIRE |
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