VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort
| Autor: | Lastraioli, E, Boni, L, Romoli, Mr, Crescioli, S, Taddei, A, Beghelli, Stefania, Tomezzoli, Anna, Vindigni, C, Saragoni, L, Messerini, L, Bernini, M, Bencini, L, Giommoni, E, Freschi, G, Di Costanzo, F, Scarpa, Aldo, Morgagni, P, Farsi, M, Roviello, F, DE MANZONI, Giovanni, Bechi, P, Arcangeli, A, Gruppo Italiano di Ricerca Cancro Gastrico |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Adult Male Vascular Endothelial Growth Factor A Pathology medicine.medical_specialty VEGF-A Gastric cancer Immunohistochemistry Prognostic markers Multivariate analysis VEGF receptors Gastric carcinoma VEGF Adenocarcinoma VEGF-A Cohort Studies Prognostic markers Stomach Neoplasms Gastric cancer Immunohistochemistry Internal medicine medicine Humans Clinical significance Pathological Aged biology business.industry Univariate Cancer General Medicine Middle Aged medicine.disease Prognosis Logistic Models Italy Cohort biology.protein Surgery Female business |
| Popis: | Purpose The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens. Methods VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters. Results In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis. Conclusions Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|