Decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease
| Autor: | Michiaki Fukui, Muhei Tanaka, Tetsuro Yamane, Hiroshi Okada, Hirokazu Oyamada, Takashi Yasuda, Takashi Nishi, Hisahiro Norikae, Yuki Okada, Tetsuya Fujita |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Science Cardiology Diseases Type 2 diabetes Disease Kaplan-Meier Estimate 030204 cardiovascular system & hematology Cardiovascular System Article 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Internal medicine medicine Outpatient clinic Humans Aged Proportional Hazards Models Retrospective Studies Multidisciplinary business.industry Proportional hazards model Hazard ratio 030208 emergency & critical care medicine Retrospective cohort study medicine.disease Peripheral Perfusion Index Survival Rate Quartile Diabetes Mellitus Type 2 Cardiovascular Diseases Medicine Female business Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Cardiovascular disease (CVD) is still the major cause of mortality in patients with type 2 diabetes. Despite of recent therapies, mortality and resources spent on healthcare due to CVD is still important problem. Thus, appropriate markers are needed to predict poor outcomes. Therefore, we investigated the role of peripheral perfusion as an indicator for cardiovascular death in patients with type 2 diabetes and established CVD. This retrospective cohort study included 1080 patients with type 2 diabetes and history of CVD recruited from the outpatient clinic at Matsushita Memorial Hospital in Osaka, Japan. Peripheral perfusion is assessed using the perfusion index (PI), which represents the level of circulation through peripheral tissues. The median age and PI values were 74 years (range: 67–79 years) and 2.6% (range: 1.1–4.3%), respectively. During follow-up duration, 60 patients died due to CVD. The adjusted Cox regression analysis demonstrated that the risk of developing cardiovascular death was higher in the first quartile (Hazard ratio, 6.23; 95% CI, 2.28 to 22.12) or second quartile (Hazard ratio, 3.04; 95% CI, 1.46 to 6.85) of PI than that in the highest quartile (fourth quartile) of PI. PI (per 1% decrease) was associated with the development of cardiovascular death (Hazard ratio, 1.39; 95% CI, 1.16 to 1.68). PI could be a novel indicator of cardiovascular death in patients with type 2 diabetes and established CVD. |
| Databáze: | OpenAIRE |
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