The effects of thalidomide in a rat model of surgically-induced endometriosis
| Autor: | Salih Serin, Murat Bakacak, Önder Ercan, Fatma Inanc, Ozan Balakan, Gurkan Kiran, Mehmet Sühha Bostancı, Aslı Yaylalı, Bülent Köstü |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
endometriosis
medicine.medical_specialty medicine.medical_treatment Rat model Endometriosis lcsh:Medicine lcsh:Gynecology and obstetrics Gastroenterology Oral gavage thalidomide Internal medicine Medicine Animal model Clinical Investigation Saline lcsh:RG1-991 Homologous transplantation vascular endothelial growth factor biology business.industry lcsh:R Obstetrics and Gynecology medicine.disease Thalidomide Myeloperoxidase biology.protein Implant business medicine.drug |
| Zdroj: | Turkish Journal of Obstetrics and Gynecology, Vol 12, Iss 3, Pp 125-131 (2015) Turkish Journal of Obstetrics and Gynecology |
| ISSN: | 1307-699X |
| Popis: | Objective: The aim of the study was to analyze the anti-angiogenic role of thalidomide and to assess whether thalidomide had any influence on a rat model of surgically-induced endometriosis. Materials and Methods: Endometriosis was induced through surgical induction and homologous transplantation in 16 rats. The rats were randomly separated into two groups as thalidomide (n=8) and control (n=8) groups. Using oral gavage, 100 mg/kg thalidomide 0.5 ml was administered to the first group and saline 0.5 ml to the control group. Histopathologic findings and volume analysis of implants were evaluated after 4 weeks. Vascular endothelial growth factor-A (VEGF-A) and oxidative markers were run from the fluid through peritoneal lavage. Results: The average implant volume decreased significantly in the thalidomide administrated group after treatment (53.3 and 22.9 mm3 respectively, p=0.012). Significant differences observed in the histopathologic scores of the thalidomide group (3 and 1 respectively, p=0.012) were not observed in the control group. Significant decreases were observed in the levels of VEGF-A and myeloperoxidase (MPO) from oxidative markers (p=0.004, p=0.037, respectively). Conclusion: Thalidomide provides volumetric and histopathologic recovery in implants particularly because the VEGF inhibition and anti-angiogenic effect, which suggests that it could be effective in the treatment of endometriosis. |
| Databáze: | OpenAIRE |
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