Relation of a novel fibrosis marker and post-myocardial infarction left ventricular ejection fraction in revascularized patients
| Autor: | Süleyman Sezai Yıldız, Ertuğrul Altınbilek, Gokhan Cetinkal, Serhat Sığırcı, Kadriye Orta Kilickesmez, Betul Balaban Kocas, Hakan Kilci |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Systole Clinical Biochemistry Myocardial Infarction Infarction Interquartile range Fibrosis Internal medicine Diabetes mellitus Drug Discovery Troponin I medicine Myocardial Revascularization Humans Aged Heart Failure Ejection fraction business.industry Biochemistry (medical) Stroke Volume Odds ratio Middle Aged medicine.disease Logistic Models ROC Curve Heart failure Multivariate Analysis Cardiology ST Elevation Myocardial Infarction Female business Biomarkers |
| Zdroj: | Biomarkers in medicine. 15(17) |
| ISSN: | 1752-0371 |
| Popis: | Aim: To investigate the relationship between post-myocardial infarction (MI) left ventricular ejection fraction (LVEF) and fibrosis marker HE-4 in primarily revascularized patients with ST-segment elevation MI (STEMI). Patients & methods: In 94 consecutive STEMI patients (median age 57 [IQR: 50–69] years; 77.7% male), HE-4 values were measured at hospital admission and 4 days after STEMI. Transthoracic echocardiography was performed 4 days after STEMI (median 5 days [interquartile range: 4–6]). Results: HE-4 levels 4 days after STEMI were significantly higher in the low ejection fraction group (30.1 [26.0–46.5] pmol/l vs 48.5 [32.5–85.9] pmol/l, p = 0.004). In the multivariable analysis, HE-4 values (odds ratio: 1.029, 95% CI: 1.012–1.046, p = 0.001), troponin I levels, anterior MI and diabetes mellitus were independent predictors of low LVEF after STEMI. A negative correlation existed between ΔHE-4 levels and LVEF (r: -0.337, p = 0.001). Receiver operating characteristic analysis indicated 34.01 pmol/l HE-4 at 4 days after STEMI identified patients with low LVEF (AUC = 0.707; 95% CI: 0.601–0.813; p = 0.001). Conclusion: In revascularized STEMI patients, high HE-4 levels are associated with decreased LVEF. HE-4 may represent a diagnostic marker and treatment target for patients with heart failure or left ventricular systolic dysfunction after STEMI. |
| Databáze: | OpenAIRE |
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