Prior exposure to endotoxin exacerbates lipopolysaccharide-induced hypoxemia and alveolitis in anesthetized swine
| Autor: | V. A. Larkin, Brian O'Sullivan, Hailong Wang, Mitchell P. Fink, P S Wollert, Robert C. Allen, Michael J. Menconi |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Lipopolysaccharides
Male Time Factors Lipopolysaccharide Swine Partial Pressure Premedication Pulmonary Fibrosis Prostacyclin Blood Pressure 6-Ketoprostaglandin F1 alpha Lung injury Pharmacology Critical Care and Intensive Care Medicine Drug Administration Schedule Hypoxemia Thromboxane A2 chemistry.chemical_compound medicine Animals Cardiac Output Hypoxia business.industry Tumor Necrosis Factor-alpha Hypoxia (medical) medicine.disease Pulmonary hypertension Shock Septic Thromboxane B2 Endotoxins Oxygen chemistry Immunology Emergency Medicine lipids (amino acids peptides and proteins) Vascular Resistance medicine.symptom business Bronchoalveolar Lavage Fluid medicine.drug |
| Zdroj: | Shock (Augusta, Ga.). 2(5) |
| ISSN: | 1073-2322 |
| Popis: | We sought to determine whether a standardized "priming" event, namely a small dose of LPS, would alter physiological responses to a subsequent larger "challenge" dose of endotoxin. Accordingly, four groups of pigs (N = 5-6) were studied. One group received neither priming nor challenge doses of LPS. A second group were not primed but were infused with a challenge dose (250 micrograms/kg) of LPS. A third group were pretreated 18 h before being studied with a priming dose of LPS (20 micrograms/kg), but were not infused with a second dose of LPS. A fourth group received both priming and challenge doses of LPS. Priming with LPS exacerbated endotoxin-induced arterial hypoxemia, and decreased animal-to-animal variability in the degree of hypoxemia induced by a challenge dose of endotoxin. Priming blunted the early phase (30 min) and exacerbated the delayed phase (120-210 min) of LPS-induced pulmonary hypertension. Priming blunted LPS-induced release of prostacyclin and thromboxane A2. The use of a priming dose of LPS increases the severity and reproducibility of LPS-induced acute lung injury in swine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|