Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology

Autor:	Izumi Kawachi, Takashi Morita, Hitoshi Takahashi, Chun-Feng Tan, Keisuke Iwanaga, Yasuhiro Hoshi, Megumi Yamada, Isao Hozumi, Osamu Onodera, Yasushi Nishihira, Masatoyo Nishizawa, Akiyoshi Kakita, Mitsuhiro Tsujihata
Rok vydání:	2008
Předmět:	Male Nervous system Pathology medicine.medical_specialty Time Factors Central nervous system Hippocampal formation Biology Hippocampus Pathology and Forensic Medicine Cellular and Molecular Neuroscience Anterior Horn Cells medicine Humans Amyotrophic lateral sclerosis Microscopy Immunoelectron Cerebrum Aged Inclusion Bodies Neurons Ubiquitin Dentate gyrus Amyotrophic Lateral Sclerosis Brain Middle Aged Spinal cord medicine.disease Immunohistochemistry Multisystem proteinopathy DNA-Binding Proteins Substantia Nigra medicine.anatomical_structure Spinal Cord Dentate Gyrus Female Autopsy Neurology (clinical) Neuroglia Brain Stem
Zdroj:	Acta Neuropathologica. 117:45-53
ISSN:	1432-0533 0001-6322
Popis:	Recently, sporadic amyotrophic lateral sclerosis (SALS), a fatal neurological disease, has been shown to be a multisystem proteinopathy of TDP-43 in which both neurons and glial cells in the central nervous system are widely affected. In general, the natural history of SALS is short (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56383b318000faf7d3819d23cf8b95ee https://doi.org/10.1007/s00401-008-0443-6 Zobrazit plný text záznamu Full text from SpringerLink