Prognostic Factors and Expression of MDM2 in Patients with Primary Extremity Liposarcoma
| Autor: | André Mathias Baptista, Renée Zon Filippi, Olavo Pires de Camargo, Claudia Mendes de Oliveira, Marcelo Tadeu Caiero, Rosalvo Zósimo Bispo Júnior |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Biopsy Clinical Sciences Soft Tissue Neoplasms Liposarcoma Gastroenterology Disease-Free Survival Young Adult Sex Factors Liposarcoma/pathology Internal medicine medicine Overall survival Biomarkers Tumor Humans In patient Young adult Pathological Aged Aged 80 and over lcsh:R5-920 biology medicine.diagnostic_test Liposarcoma^i1^ssurg business.industry Age Factors Proto-oncogenic proteins Extremities Proto-Oncogene Proteins c-mdm2 General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry biology.protein Mdm2 Female Liposarcoma/surgery Liposarcoma^i1^spathol Neoplasm Recurrence Local business lcsh:Medicine (General) Follow-Up Studies |
| Zdroj: | Clinics (Sao Paulo, Brazil) Clinics, Volume: 63, Issue: 2, Pages: 157-164, Published: 2008 Clinics, Vol 63, Iss 2, Pp 157-164 (2008) Clinics; v. 63 n. 2 (2008); 157-164 Clinics; Vol. 63 Núm. 2 (2008); 157-164 Clinics; Vol. 63 No. 2 (2008); 157-164 Clinics Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVE: The objective of this study was to investigate MDM2 (murine double minute 2) protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival and overall survival in patients with primary liposarcomas of the extremities. MATERIALS AND METHODS: Of 50 patients with primary liposarcomas of the extremities admitted to a Reference Service, between 1968 and 2004, 25 were enrolled in the study, following eligibility and exclusion criteria. RESULTS: The adverse factors that influenced the risk for local recurrence in the univariant analysis included male sex (P = 0.023), pleomorphic histological subtype (P = 0.027), and high histological grade (P = 0.007). Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis. Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003). CONCLUSIONS: There was no correlation between immunohistochemically observed MDM2 protein expressions and the anatomical and pathological variables studied. The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival). The immunoexpression of MDM2 protein was a frequent event in the different subtypes of liposarcomas. |
| Databáze: | OpenAIRE |
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