Higher GABA concentration in the medial prefrontal cortex of Type 2 diabetes patients is associated with episodic memory dysfunction

Autor: David G. Norris, Evrim Anadol-Schmitz, Sofiya Gancheva, Jan Willem Thielen, Indira Tendolkar, Michael Roden, Maria Apostolopoulou, Donghyun Hong, Bixia Chen, Seyedmorteza Rohani Rankouhi
Přispěvatelé: Magnetic Detection and Imaging
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Magnetic Resonance Spectroscopy
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]
Precuneus
Medizin
chemistry.chemical_compound
0302 clinical medicine
130 000 Cognitive Neurology & Memory
Prefrontal cortex
Neurotransmitter
Episodic memory
gamma-Aminobutyric Acid
Research Articles
Radiological and Ultrasound Technology
biology
05 social sciences
Diabetes
Glutamate receptor
Middle Aged
medicine.anatomical_structure
Neurology
Female
Anatomy
Adult
medicine.medical_specialty
Memory
Episodic
Biophysics
Prefrontal Cortex
Inhibitory postsynaptic potential
150 000 MR Techniques in Brain Function
050105 experimental psychology
03 medical and health sciences
Insulin resistance
Memory
Internal medicine
medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Memory Disorders
business.industry
Magnetic Resonance Spectroscopy (MRS)
medicine.disease
Insulin receptor
Endocrinology
chemistry
Diabetes Mellitus
Type 2
biology.protein
Neurology (clinical)
business
human activities
030217 neurology & neurosurgery
Zdroj: Hum Brain Mapp
Human brain mapping, 40(14), 4287-4295. Wiley-Liss Inc.
Human Brain Mapping, 40, 4287-4295
Human Brain Mapping, 40, 14, pp. 4287-4295
ISSN: 1065-9471
DOI: 10.1002/hbm.24702
Popis: Contains fulltext : 209018.pdf (Publisher’s version ) (Closed access) Type 2 diabetes (T2D) is associated with an accelerated episodic memory decline, but the underlying pathophysiological mechanisms are not well understood. Hallmarks of T2D comprise impairment of insulin secretion and insulin sensitivity. Insulin signaling modulates cerebral neurotransmitter activity, including the excitatory glutamate and inhibitory gamma-aminobutyric acid (GABA) systems. Here we tested the hypothesis that the glutamate and GABA systems are altered in T2D patients and this relates to memory decline and insulin resistance. Using (1) H-magnetic resonance spectroscopy (MRS), we examined glutamate and GABA concentrations in episodic memory relevant brain regions (medial prefrontal cortex and precuneus) of T2D patients and matched controls. Insulin sensitivity was measured by hyperinsulinemic-euglycemic clamps and memory performance was assessed using a face-profession associations test. T2D patients exhibited peripheral insulin resistance and had a decreased memory for face-profession associations as well as elevated GABA concentration in the medial prefrontal cortex but not precuneus. In addition, medial prefrontal cortex GABA concentration was negatively associated with memory performance suggesting that abnormal GABA levels in the medial prefrontal cortex are linked to the episodic memory decline that occurs in T2D patients.
Databáze: OpenAIRE
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