| Autor: |
Fett, Sarah, Mujtahid Rahman, Tse, Vincent, Vargas, Aida, Kapinos, Andrew, Canela Torres, Krisanavane Reddi, Parker, Jordan Moberg, Freise, Amanda |
| Rok vydání: |
2020 |
| DOI: |
10.6084/m9.figshare.12616715.v1 |
| Popis: |
Arthrobacter globiformis phage Whytu was isolated from a California soil sample; sequencing revealed one of the smallest Actinobacteriophage genomes. Using comparative genomics, we compared Whytu to other Actinobacteriophages that infect different hosts. Previous studies show that phages with smaller genomes have similar gene products and amino acid sequences, even among different hosts. In addition, PhagesDB BLAST yielded significant hits with cluster FE phages and the singleton BlueFeather. Unexpectedly, Whytu has minimal nucleotide similarity with FE phages and BlueFeather, despite extensive gene content and pham similarity. SplitsTree analysis of shared phams indicated segregation of Whytu and other small-genome phages into two distinct groups. Though there are no ubiquitous pham similarities among all studied phages, there are some conserved genes within certain clusters, such as with Lysin A in cluster FI. Studying these genomic trends may advance novel phage characterization by observation of unexplored grouping patterns. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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