Staging of necrotising enterocolitis by Bell's criteria is supported by a statistical pattern analysis of clinical and radiological variables
| Autor: | Mathias Lühr Hansen, Gorm Greisen, Magdalena Gormsen, Sandra Meinich Juhl, Thomas Skov |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Disease onset Denmark Statistical pattern Population Infant Premature Diseases Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Necrotising enterocolitis Enterocolitis Necrotizing 030225 pediatrics medicine Spontaneous Intestinal Perforation Humans 030212 general & internal medicine Neonatology education Staging system Retrospective Studies education.field_of_study Principal Component Analysis business.industry General surgery Infant Newborn General Medicine digestive system diseases Radiography Intestinal Perforation Radiological weapon Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 108(5) |
| ISSN: | 1651-2227 |
| Popis: | AIM Necrotising enterocolitis (NEC) is often staged according to Bell's 1978 system, but today's NEC cases are more immature than the ones that were used to develop Bell's stages. Our aim was to explore the clinical and radiographic findings of contemporary cases of NEC and spontaneous intestinal perforation. METHODS We coded the clinical records of all cases of NEC stages I-III and spontaneous intestinal perforation born in 2006-2015 at the tertiary department of neonatology at Rigshospitalet, Denmark, for 16 clinical and radiographic symptoms and signs at disease onset and at climax. These variables were explored using principal component analysis, which can detect patterns in large datasets. RESULTS We reviewed 640 clinical records and included 158 cases of NEC or spontaneous intestinal perforation. When we entered the clinical and radiographic signs at disease climax, the cases were roughly grouped according to Bell's stages, except for a small group of NEC III cases, who were grouped with the cases of spontaneous intestinal perforation. CONCLUSION An analysis of the pattern of clinical and radiographic findings in a 2006-2015 population of NEC cases supported Bell's 1978 staging system. However, the separation between NEC and spontaneous intestinal perforation still poses a difficult task. |
| Databáze: | OpenAIRE |
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