Potato Peels and Their Bioactive Glycoalkaloids and Phenolic Compounds Inhibit the Growth of Pathogenic Trichomonads
| Autor: | Quincel Quiambao, Ohkun Kwon, Jenny Liu, Carol Levin, Joseph Young, Christina C. Tam, Luisa W. Cheng, Kirkwood M. Land, Sirisha Chintalapati, Mendel Friedman, Vincent Huang, Sabrina M. Noritake |
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| Rok vydání: | 2018 |
| Předmět: |
genetic structures
Antiprotozoal Agents Cattle Diseases Trichomonas Infections Cat Diseases medicine.disease_cause 01 natural sciences Waste product chemistry.chemical_compound Alkaloids 0404 agricultural biotechnology Phenols Chlorogenic acid medicine Caffeic acid Animals Food science Chromatography High Pressure Liquid Solanum tuberosum Plant Extracts fungi 010401 analytical chemistry food and beverages 04 agricultural and veterinary sciences General Chemistry 040401 food science eye diseases In vitro 0104 chemical sciences Potato processing Plant Tubers chemistry Cats Trichomonas Cattle Trichomonas vaginalis sense organs Growth inhibition General Agricultural and Biological Sciences |
| Zdroj: | Journal of Agricultural and Food Chemistry. 66:7942-7947 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.8b01726 |
| Popis: | Potato peel, a waste product of the potato processing industry, is high in bioactive compounds. We investigated the in vitro antitrichomonad activity of potato peel powders prepared from commercial Russet, red, purple, and fingerling varieties as well as several known potato components, alkaloids and phenolic compounds, against three pathogenic strains of trichomonads. Trichomonas vaginalis is a sexually transmitted protozoan parasite that causes the human disease trichomoniasis. Two distinct strains of the related Tritrichomonas fetus infect cattle and cats. The glycoalkaloids α-chaconine and α-solanine were highly active against all parasite lines, while their common aglycone solanidine was only mildly inhibitory. α-Solanine was several times more active than α-chaconine. The phenolic compounds caffeic and chlorogenic acids and quercetin were mildly active against the parasites. Most of the potato peel samples were at least somewhat active against all three trichomonad species, but their activities were wide-ranging and did not correspond to their glycoalkaloid and phenolic content determined by HPLC. The two Russet samples were the most active against all three parasites. The purple potato peel sample was highly active against bovine and mostly inactive against feline trichomonads. None of the test substances were inhibitory toward several normal microflora species, suggesting the potential use of the peels for targeted therapeutic treatments against trichomonads. |
| Databáze: | OpenAIRE |
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