Systematic Review: Medication Effects on Brain Intrinsic Functional Connectivity in Patients With Attention-Deficit/Hyperactivity Disorder
| Autor: | Michael P. Milham, Cesar Soutullo, Alexandre Rosa Franco, Victor Pereira-Sanchez, Francisco X. Castellanos, Dorice Vieira, Pilar de Castro-Manglano |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Atomoxetine Hydrochloride Developmental and Educational Psychology medicine Humans Attention deficit hyperactivity disorder 0501 psychology and cognitive sciences In patient Child Neural correlates of consciousness medicine.diagnostic_test Resting state fMRI business.industry Methylphenidate 05 social sciences Atomoxetine Brain Reproducibility of Results medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Attention Deficit Disorder with Hyperactivity Sample size determination Central Nervous System Stimulants Female Functional magnetic resonance imaging business 050104 developmental & child psychology medicine.drug Clinical psychology |
| Zdroj: | Journal of the American Academy of Child & Adolescent Psychiatry. 60:222-235 |
| ISSN: | 0890-8567 |
| DOI: | 10.1016/j.jaac.2020.10.013 |
| Popis: | Objective Resting-state functional magnetic resonance imaging (R-fMRI) studies of the neural correlates of medication treatment in attention-deficit/hyperactivity disorder (ADHD) have not been systematically reviewed. Our objective was to systematically identify, assess and summarize within-subject R-fMRI studies of pharmacological-induced changes in patients with ADHD. We critically appraised strengths and limitations, and provide recommendations for future research. Method Systematic review of published original reports in English meeting criteria in pediatric and adult patients with ADHD up to July 1, 2020. A thorough search preceded selection of studies matching prespecified criteria. Strengths and limitations of selected studies, regarding design and reporting, were identified based on current best practices. Results We identified and reviewed 9 studies (5 pediatric and 4 adult studies). Sample sizes were small-medium (16–38 patients), and included few female participants. Medications were methylphenidate, amphetamines, and atomoxetine. Wide heterogeneity was observed in designs, analyses and results, which could not be combined quantitatively. Qualitatively, the multiplicity of brain regions and networks identified, some of which correlated with clinical improvements, do not support a coherent mechanistic hypothesis of medication effects. Overall, reports did not meet current standards to ensure reproducibility. Conclusion In this emerging field, the few studies using R-fMRI to analyze the neural correlates of medications in patients with ADHD suggest a potential modulatory effect of stimulants and atomoxetine on several intrinsic brain activity metrics. However, methodological heterogeneity and reporting issues need to be addressed in future research to validate findings which may contribute to clinical care. Such a goal is not yet at hand. |
| Databáze: | OpenAIRE |
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