Carcinogenesis and Bacillus Calmette-Guérin (BCG) Intravesical Treatment of Non-Muscle-Invasive Bladder Cancer under Tryptophan and Thymine Supplementation
| Autor: | Guilherme Z. Rocha, Karen L. Ferrari, Isis G. A. Kiehl, Leonardo Oliveira Reis, Marina V Ossick, Maria C B Linarelli, Ana Clara Salustiano, Giovanna Rosa Degasperi, Heloisa Balan Assalin |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Carcinogenesis Medicine (miscellaneous) medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adjuvants Immunologic medicine Animals 030109 nutrition & dietetics Nutrition and Dietetics Bladder cancer Multiple cancer business.industry Tryptophan medicine.disease Thymine Administration Intravesical Intravesical treatment Urinary Bladder Neoplasms Oncology chemistry Cell culture 030220 oncology & carcinogenesis Dietary Supplements BCG Vaccine Cancer research Non muscle invasive business |
| Zdroj: | Nutrition and Cancer. 73:2687-2694 |
| ISSN: | 1532-7914 0163-5581 |
| Popis: | Evaluate tryptophan and thymine (TT) impact on carcinogenesis and intravesical BCG bladder cancer treatment.After identification of TT in vitro inhibitory effect in multiple cancer cell cultures, bladder cancer animal model was induced by MNU intravesical instillations and randomized into four groups: Control (Urothelial cancer was identified in 100%, 85.7%, 44.5%, and 37.5% of Control, TT, BCG, and BCG + TT groups, respectively. Cell proliferation marked by nuclear Ki-67 was higher in the Control compared to animals in the other groups (TT inhibit urothelial carcinogenesis and potentiate the intravesical BCG in the treatment of bladder cancer by reducing cell proliferation and activating TLRs. |
| Databáze: | OpenAIRE |
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