High throughput research and evaporation rate modeling for solvent screening for ethylcellulose barrier membranes in pharmaceutical applications
| Autor: | True L. Rogers, Cody A. Schoener, Michael P. Tate, Jaime L. Curtis-Fisk |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Chemistry Pharmaceutical Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Dosage form 2-Propanol 03 medical and health sciences chemistry.chemical_compound Viscosity 0302 clinical medicine Drug Discovery Acetone Organic chemistry Cellulose Pharmacology Ethanol Organic Chemistry Water 021001 nanoscience & nanotechnology Evaporation (deposition) Casting Solutions Solvent Membrane chemistry Chemical engineering Solvents Methanol 0210 nano-technology |
| Zdroj: | Drug Development and Industrial Pharmacy. 42:1700-1707 |
| ISSN: | 1520-5762 0363-9045 |
| Popis: | Ethylcellulose is commonly dissolved in a solvent or formed into an aqueous dispersion and sprayed onto various dosage forms to form a barrier membrane to provide controlled release in pharmaceutical formulations. Due to the variety of solvents utilized in the pharmaceutical industry and the importance solvent can play on film formation and film strength it is critical to understand how solvent can influence these parameters.To systematically study a variety of solvent blends and how these solvent blends influence ethylcellulose film formation, physical and mechanical film properties and solution properties such as clarity and viscosity.Using high throughput capabilities and evaporation rate modeling, thirty-one different solvent blends composed of ethanol, isopropanol, acetone, methanol, and/or water were formulated, analyzed for viscosity and clarity, and narrowed down to four solvent blends. Brookfield viscosity, film casting, mechanical film testing and water permeation were also completed.High throughput analysis identified isopropanol/water, ethanol, ethanol/water and methanol/acetone/water as solvent blends with unique clarity and viscosity values. Evaporation rate modeling further rank ordered these candidates from excellent to poor interaction with ethylcellulose. Isopropanol/water was identified as the most suitable solvent blend for ethylcellulose due to azeotrope formation during evaporation, which resulted in a solvent-rich phase allowing the ethylcellulose polymer chains to remain maximally extended during film formation. Consequently, the highest clarity and most ductile films were formed.Employing high throughput capabilities paired with evaporation rate modeling allowed strong predictions between solvent interaction with ethylcellulose and mechanical film properties. |
| Databáze: | OpenAIRE |
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