Normal reference intervals of prognostic nutritional index in healthy adults: A large multi‐center observational study from Western China

Autor: Linbo He, Yaping Chen, Dongsheng Wang, Huaichao Luo, Hailin Yin, Guishu Yang, Ying Lin, Tian Li, Jianhong Yu, Guangjie Zhang
Rok vydání: 2021
Předmět:
Adult
Male
0301 basic medicine
Microbiology (medical)
China
medicine.medical_specialty
Han chinese
Adolescent
Clinical Biochemistry
Young Adult
03 medical and health sciences
0302 clinical medicine
Age groups
Reference Values
multi‐center study
Internal medicine
cohort study
medicine
Humans
Immunology and Allergy
Research Articles
Aged
business.industry
Biochemistry (medical)
Public Health
Environmental and Occupational Health
Reproducibility of Results
Retrospective cohort study
Hematology
Middle Aged
prognostic nutritional index
reference interval
Reference intervals
Medical Laboratory Technology
Nutrition Assessment
030104 developmental biology
Health
030220 oncology & carcinogenesis
Multi center study
Female
observational study
Observational study
business
Research Article
Cohort study
Surgical patients
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
0887-8013
DOI: 10.1002/jcla.23830
Popis: Background It has been widely reported that the prognostic nutritional index (PNI) played a pivotal role in nutritional assessment of surgical patients and tumor prognosis. In order to improve the accuracy of evaluation in Western China, we established reference intervals (RIs) of PNI in healthy controls. Methods A retrospective cohort study on healthy ethnic Han adults (18–79 years) was conducted to explore the influences of age, gender, study centers, and instruments on PNI and to establish RIs. The data came from a healthy routine examination center database and laboratory information system (LIS) of four centers in Western China, and there were 200 persons selected randomly for verification of RIs. Results Five thousand eight hundred and thirty‐nine healthy candidates were enrolled. PNI showed a marked gender dependence, and males had significantly higher PNI than females across all ages (p
A retrospective cohort study on healthy ethnic Han adults (18–79 years) was conducted to explore the influences of age, gender, study centers, and instruments on prognostic nutritional index (PNI) and to establish reference intervals (RIs). We established reference intervals of PNI in healthy Han Chinese population in Western China, and validated successfully. Further established RIs will lead to better standardizations of PNI for clinical applications.
Databáze: OpenAIRE
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