Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease
| Autor: | F. Guillamón, Julián Benito-León, R. Enríquez-de-Salamanca, Joaquín Arenas, M. Ortí-Pareja, JoséAntonio Molina, Teresa Gasalla, Juan C. Rubio, A. Tallón-Barranco, F J Jiménez-Jiménez, F. de Bustos |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Antioxidant medicine.medical_treatment Central nervous system disease chemistry.chemical_compound Cerebrospinal fluid Alzheimer Disease Internal medicine Humans Vitamin E Medicine Biological Psychiatry Aged Aged 80 and over Analysis of Variance business.industry Lumbosacral Region medicine.disease Psychiatry and Mental health Endocrinology Neurology chemistry Case-Control Studies Linear Models Female Neurology (clinical) Alzheimer's disease business alpha-Tocopherol Body mass index |
| Zdroj: | Journal of Neural Transmission. 104:703-710 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/bf01291887 |
| Popis: | We compared CSF and serum levels, and the CST/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 44 apparently well-nourished patients with Alzheimer's disease (AD) and 37 matched controls. CSF and serum vitamin E levels were correlated, both in AD patients and in controls. The mean CSF and serum vitamin E levels were significantly lower in AD patients, and the CSF/serum ratio of AD patients did not differ significantly between the 2 study groups. CSF vitamin E levels did not correlate with age, age at onset, duration of the disease and score of the Minimental State Examination in the AD group. Weight and body mass index were significantly lower in AD patients than in controls. These results suggest that low CSF and serum vitamin E concentrations in AD patients could be related with a deficiency of dietary intake of vitamin E. |
| Databáze: | OpenAIRE |
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