Role of 18F-FDG PET/CT in staging and follow-up of lymphoma in pediatric and young adult patients
| Autor: | Ur Metser, Isaac Yaniv, Amos Toren, Dalia Valdman, Yoav Burstein, Galia Avrahami, Elka Miller, Einat Even-Sapir, Rina Dvir, Dror Sayar, Liat Ben Sira |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Lymphoma Disease Malignant disease Fluorodeoxyglucose F18 Predictive Value of Tests Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Young adult Child Neoplasm Staging Retrospective Studies PET-CT business.industry Retrospective cohort study medicine.disease Predictive value of tests Child Preschool Fdg pet ct Female Radiology Nuclear medicine business Tomography X-Ray Computed Tomography Emission-Computed |
| Zdroj: | Journal of computer assisted tomography. 30(4) |
| ISSN: | 0363-8715 |
| Popis: | Objective: To assess the role of 18 F-Fluorodeoxyglucose ( 18 F-FDG) PET/CT in pediatric patients with Hodgkin disease (HD) and non-Hodgkin lymphoma (NHL). Materials and Methods: 31 patients, mean age 12.9 ± 5.1, HD (n = 24), and NHL (n = 7) underwent 18 F-FDG PET/CT at diagnosis (n = 31 studies) and later in the course of the disease (n = 75 studies). The findings of PET/CT were correlated with diagnostic CT and clinical follow-up. Results: PET/CT findings resulted in a change of disease staging in 10 patients (32.3%), upstaging in 7 (22.6%) and downstaging in 3 (9.6%). On a lesion analysis, 164 disease sites were detected by PET/ CT of which 38 were overlooked by DCT. At mid-treatment, PET was negative in 28 out of 31 patients (90%) with negative predictive value of 96% as all latter patients except for 1, were disease free (mean 15.4 ± 8.8 months). The positive predictive value of persistent increased 18 F-FDG uptake was 100% as 3 patients with latter findings had active disease. On the CT part, 76 residual masses were identified in 22 patients. Increased 18 F-FDG uptake was detected in 11 masses in 4 patients who had active disease. Remaining 65 PET negative masses were false positive findings. The positive predictive value of residual CT mass was 14%. Conclusions: PET/CT is associated with change in staging in approximately 1 out of 3 pediatric patients with HD and NHL. When used for monitoring response to treatment, a negative study is associated with disease-free period, even when residual mass is detected. A positive PET study indicates residual malignant disease. |
| Databáze: | OpenAIRE |
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