Copper-Catalyzed Single C–H Amination of 8-Aminoquinoline-Directed Ferrocenes
| Autor: | Shin-ichi Fukuzawa, Kazuya Kanemoto, Nao Horikawa, Yuichiro Tokoro, Shun Hoshino |
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| Rok vydání: | 2021 |
| Předmět: |
8-Aminoquinoline
010405 organic chemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Copper Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Functional importance Amide Rapid access Copper catalyzed Physical and Theoretical Chemistry Amination |
| Zdroj: | Organic Letters. 23:4966-4970 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.1c01294 |
| Popis: | An unprecedented copper-catalyzed C-H monoamination of ferrocenes directed by an 8-aminoquinoline amide directing group is described. This reaction proceeds in the presence of a catalytic amount of copper catalyst with both cyclic and acyclic amines to afford the various aminoferrocenes. The C-H amination of ortho-substituted ferroceneamides was also achieved, enabling rapid access to multisubstituted ferrocenes that are useful for developing new functional molecules. |
| Databáze: | OpenAIRE |
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