A new generation computerised metacognitive cognitive remediation programme for schizophrenia (CIRCuiTS): a randomised controlled trial
| Autor: | Rumina Taylor, Vyv Huddy, Matteo Cella, Clare Reeder, Til Wykes, Kathryn Greenwood, Sabine Landau |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
cognition
medicine.medical_specialty Psychotherapist neuropsychology law.invention 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Randomized controlled trial law Journal Article medicine Cognitive rehabilitation therapy Cognitive skill psychosis Applied Psychology Neuropsychology Cognition Original Articles Executive functions medicine.disease 030227 psychiatry Psychiatry and Mental health social functioning Cognitive remediation therapy Schizophrenia cognitive remediation Psychology metacognition 030217 neurology & neurosurgery |
| Zdroj: | Psychological Medicine Reeder, C, Huddy, V, Cella, M, Taylor, R, Greenwood, K, Landau, S & Wykes, T 2017, ' A new generation computerised metacognitive cognitive remediation programme for schizophrenia (CIRCuiTS) : a randomised controlled trial ', Psychological Medicine, vol. 47, no. 15, pp. 2720-2730 . https://doi.org/10.1017/S0033291717001234 |
| ISSN: | 0033-2917 |
| Popis: | BackgroundCognitive remediation (CR) is a psychological therapy, which improves cognitive and social functioning in people with schizophrenia. It is now being implemented within routine clinical services and mechanisms of change are being explored. We designed a new generation computerised CR programme, CIRCuiTS (Computerised Interactive Remediation of Cognition – a Training for Schizophrenia), to enhance strategic and metacognitive processing, with an integrated focus on the transfer of cognitive skills to daily living. This large trial tested its feasibility to be delivered in therapist-led and independent sessions, and its efficacy for improved cognitive and social functioning.MethodsA two arm single blind randomised superiority trial comparing CIRCuiTS plus treatment-as-usual (TAU) with TAU alone in 93 people with a diagnosis of schizophrenia. Cognitive, social functioning and symptom outcomes were assessed at pre- and post-therapy and 3 months later.Results85% adhered to CIRCuiTS, completing a median of 28 sessions. There were significant improvements in visual memory at post-treatment (p = 0.009) and follow-up (p = 0.001), and a trend for improvements in executive function at post-treatment (p = 0.056) in favour of the CIRCuiTS group. Community function was also differentially and significantly improved in the CIRCuiTS group at post-treatment (p = 0.003) but not follow-up, and was specifically predicted by improved executive functions.ConclusionsCIRCuiTS was beneficial for improving memory and social functioning. Improved executive functioning emerges as a consistent predictor of functional gains and should be considered an important CR target to achieve functional change. A larger-scale effectiveness trial of CIRCuiTS is now indicated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|