Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark
| Autor: | S. Olubusayo Awe, J. Modupe Makinde, Olumayokun A. Olajide, David T. Okpako |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Erythrocytes Fever medicine.drug_class Pain Hemorrhage Vascular permeability In Vitro Techniques Pharmacognosy Pharmacology Anti-inflammatory Plant Epidermis law.invention Mice In vivo law Oral administration Cystitis Drug Discovery Animals Edema Humans Medicine Antipyretic Rats Wistar Antineoplastic Agents Alkylating Cyclophosphamide Acetic Acid Pain Measurement Plants Medicinal Traditional medicine Plant Extracts business.industry Anti-Inflammatory Agents Non-Steroidal Euphorbiaceae Arthritis Experimental Rats visual_art visual_art.visual_art_medium Bark Phytotherapy business medicine.drug |
| Zdroj: | Journal of Ethnopharmacology. 71:153-160 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/s0378-8741(99)00201-9 |
| Popis: | The anti-inflammatory profile of the aqueous extract of Bridelia ferruginea stem bark was investigated using both in vivo and in vitro models. The extract exhibited strong topical anti-inflammatory effect shown as inhibition of croton oil-induced ear oedema in mice, and reduced hind-paw swelling and growth retardation in the adjuvant-induced arthritis model in rats, following oral administration at 10, 20, 40 or 80 mg/kg. The extract (10-80 mg/kg, p.o.) caused an inhibition of increase in vascular permeability in both cyclophosphamide-induced haemorrhagic cystitis and acetic acid-induced vascular permeability in rats and mice, respectively. B. ferruginea produced stabilization of erythrocytes exposed to heat and stress-induced lysis. Antipyretic and analgesic properties of the extract were also observed. |
| Databáze: | OpenAIRE |
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