Online study partner-reported cognitive decline in the Brain Health Registry

Autor: Diana Truran, R. Scott Mackin, Michael W. Weiner, Paul Maruff, Shannon Finley, Derek Flenniken, Monica R. Camacho, Rachel L. Nosheny, Juliet Fockler, Philip S. Insel, Kristine Yaffe, Aaron Ulbricht
Rok vydání: 2018
Předmět:
Zdroj: Alzheimer's & Dementia : Translational Research & Clinical Interventions
ISSN: 2352-8737
Popis: Introduction Methods for efficiently identifying cognitive decline and Alzheimer's disease (AD) are a critical unmet need. The goal of this work was to validate novel online study partner (SP)-reported outcomes to identify cognitive decline in older adults. Methods In older adults enrolled in the Brain Health Registry, we analyzed associations between SP-reported cognitive decline, measured by the Everyday Cognition Scale, and either (1) participant cognition, assessed by Cogstate Brief Battery or (2) participant-reported diagnosis of mild cognitive impairment or AD. Results We found strong associations between SP-reported Everyday Cognition Scale and both Cogstate scores and participant diagnosis. The associations were cognitive domain specific, dependant on participant diagnosis, and were stronger in spouse dyads and those who knew each other longer. Discussion Collecting SP-reported data online from a large cohort is feasible. Results support the construct validity of our approach, which has the potential to facilitate clinical AD and aging research.
Highlights • Online study partner (SP)-reported decline is associated with cognition. • Associations are cognitive domain specific. • Online SP-reported cognitive decline is associated with participant diagnosis. • Individuals at risk for mild cognitive impairment have greater SP-reported decline. • These aforementioned associations depend on diagnosis and dyad relationship.
Databáze: OpenAIRE
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