Chromatin, epigenetics and stem cells
| Autor: | Tim C. Roloff, Ulrike A. Nuber |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
RNA
Untranslated Histology Epigenetic regulation of neurogenesis Chromosomal Proteins Non-Histone Cellular differentiation Biology Chromatin remodeling Epigenesis Genetic Pathology and Forensic Medicine Histones Animals Humans Histone code Epigenetics ChIA-PET Epigenomics Genetics Stem Cells Cell Biology General Medicine DNA Methylation Chromatin Assembly and Disassembly Chromatin Cell biology Gene Expression Regulation |
| Zdroj: | European Journal of Cell Biology. 84:123-135 |
| ISSN: | 0171-9335 |
| DOI: | 10.1016/j.ejcb.2004.12.013 |
| Popis: | Epigenetics is a term that has changed its meaning with the increasing biological knowledge on developmental processes. However, its current application to stem cell biology is often imprecise and is conceptually problematic. This article addresses two different subjects, the definition of epigenetics and chromatin states of stem and differentiated cells. We describe mechanisms that regulate chromatin changes and provide an overview of chromatin states of stem and differentiated cells. Moreover, a modification of the current epigenetics definition is proposed that is not restricted by the heritability of gene expression throughout cell divisions and excludes translational gene expression control. |
| Databáze: | OpenAIRE |
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