Small molecule selectin ligand inhibition improves outcome in ischemic acute renal failure
| Autor: | Michael P. O'Donnell, Andrew Issekutz, John T. Crosson, Kurt Berens, Bertram L. Kasiske, William F. Keane, Melissa J. Burne, Takashi Nemoto, Frank Daniels, Hamid Rabb |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
leukocytes Ischemia Renal function Pharmacology urologic and male genital diseases Kidney Antibodies Renal Circulation Rats Sprague-Dawley delayed graft function cold kidney storage medicine.artery medicine Animals cardiovascular diseases Renal artery Peroxidase disease models business.industry urogenital system fungi Biphenyl Compounds Acute Kidney Injury medicine.disease Immunohistochemistry female genital diseases and pregnancy complications Blockade kidney failure CD4 Lymphocyte Count Rats Transplantation P-Selectin medicine.anatomical_structure Kidney Tubules Nephrology Mannosides Immunology Selectins business E-Selectin renal artery clamping Mannose Selectin Kidney disease transplantation |
| Zdroj: | Kidney international. 60(6) |
| ISSN: | 0085-2538 |
| Popis: | Small molecule selectin ligand inhibition improves outcome in genesis of renal ischemia-reperfusion injury (IRI) have ischemic acute renal failure. most commonly utilized the model of renal artery clamp- Background. The pathophysiologic and potential therapeu- ing. Post-ischemic renal injury in this model has been tic role of selectins in renal ischemia-reperfusion injury (IRI) shown to be very similar to human ischemic renal injury, is not fully understood, due in part to redundancy in the roles including that secondary to cold kidney storage prior to of individual selectins. We hypothesized that blockade of ligands for all three selectins using a novel small molecule (TBC-1269) transplantation (5, 6). However, a recent review also has would improve the course of renal IRI by overcoming redun- emphasized differences between experimental animal dancy issues. This was investigated in a rat model of renal IRI. and human acute renal failure (7). Methods. Rats were treated with TBC-1269 either during Several studies have shown that ischemia-reperfusion or post-IRI. The effects of TBC-1269 were investigated in two can stimulate renal expression of leukocyte adhesion models of renal IRI: moderate IRI (30 minutes bilateral renal artery clamping) and severe IRI (45 minutes clamping). The molecules (8, 9). Previous studies have demonstrated combination of anti-E- and anti-P-selectin antibodies also was that antibody blockade of the CD11/CD18 receptor on investigated in rats subjected to moderate IRI. Renal function, leukocytes significantly attenuated renal IRI in rats histological injury and mortality were assessed. (8, 10). Moreover, antibody blockade of intercellular ad |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|