Inflammatory markers at baseline correlate with subsequent clinical response to quetiapine in patients with bipolar disorder

Autor:	Marco Ferrari, Marco Godio, Stefano Martini, Camilla Callegari, Marco Cosentino, Franca Marino
Rok vydání:	2022
Předmět:	bipolar disorder IL-6 Interleukin-6 CRP quetiapine Blood Sedimentation Quetiapine Fumarate Psychiatry and Mental health C-Reactive Protein Neurology Humans Pharmacology (medical) Neurology (clinical) Biomarkers
Zdroj:	Human Psychopharmacology: Clinical and Experimental. 37
ISSN:	1099-1077 0885-6222
DOI:	10.1002/hup.2854
Popis:	Recent studies proposed the existence of a correlation between patients' inflammatory status and therapy response in bipolar disorder (BD). Here we investigated the correlation between levels of inflammatory markers and quetiapine (QUE) effects in BD patients.In 15 hospitalised BD patients, we investigated changes in inflammatory markers such as C-Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR) and cytokines after a 6-week treatment with QUE monotherapy.We found QUE treatment to significantly reduce CRP and IL-6 plasma levels. Moreover, we found higher CRP and IL-6 plasma levels at baseline correlated with better improvement of patients' clinical symptoms.The reported results, although preliminary, could be useful in clinical practice, providing not only markers for QUE response, but also allowing for identification of new targets and new therapies for the treatment of this condition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561c8e8ab28a9ba723caa0dc4aa7fadb https://doi.org/10.1002/hup.2854 Zobrazit plný text záznamu Plný text