Randomized Controlled Trial of the Effect of 30% versus 80% Fraction of Inspired Oxygen on Cesarean Delivery Surgical Site Infection
| Autor: | David McKenna, Melanie M Glover, Ned L Williams, Catrina Crisp, Angus L. Acton |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Operative Time Logistic regression White People Body Mass Index law.invention Young Adult symbols.namesake Double-Blind Method Randomized controlled trial Pregnancy law Fraction of inspired oxygen medicine Humans Surgical Wound Infection Fisher's exact test Postoperative Care Cesarean Section business.industry Oxygen Inhalation Therapy Obstetrics and Gynecology Perioperative Odds ratio medicine.disease Oxygen Anesthesia Pediatrics Perinatology and Child Health symbols Female business Body mass index |
| Zdroj: | American Journal of Perinatology. 30:781-786 |
| ISSN: | 1098-8785 0735-1631 |
| DOI: | 10.1055/s-0032-1333405 |
| Popis: | Objective To determine if supplemental perioperative oxygen will reduce surgical site infection (SSI) following cesarean delivery. Methods This is a randomized, controlled trial evaluating SSI following either 30% or 80% fraction of inspired oxygen (F io 2 ) during and 2 hours after cesarean delivery. Anesthesia providers administered F io 2 via a high-flow oxygen blender. Subjects, surgeons, and wound evaluation teams were blinded. Serial wound evaluations were performed. Data were analyzed using logistic regression models, Fisher exact test, and t test. Results In all, 179 women were randomized, and 160 subjects were included in the analysis. There were 12/83 (14.5%) SSIs in the control group versus 10/77 (13.0%) in the investigational group ( p = 0.82). Caucasian race, increased body mass index, and longer operative time were identified as significant risk factors for infection ( p = 0.026, odds ratio 0.283; p = 0.05, odds ratio = 1.058; p = 0.037, odds ratio = 1.038, respectively). Conclusion Perioperative oxygenation with 80% F io 2 is not effective in reducing SSI following cesarean delivery. |
| Databáze: | OpenAIRE |
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