Association of Estrogen Receptor α GenesPvuII andXbaI Polymorphisms with Type 2 Diabetes Mellitus in the Inpatient Population of a Hospital in Southern Iran
| Autor: | Mohammad Pourahmadi, Saeideh Erfanian, Farzaneh Mohammadi, Houshang Jamali, Mohadeseh Mosalanejad, Mohamed Amin Ghobadifar |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases medicine.drug_class Endocrinology Diabetes and Metabolism Population Estrogen receptor PvuII lcsh:Diseases of the endocrine glands. Clinical endocrinology Pathogenesis Genetic Diabetes mellitus Internal medicine Genetics medicine Humans education Gene XbaI education.field_of_study lcsh:RC648-665 business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus Diabetes mellitus type 2 biochemical phenomena metabolism and nutrition II bacterial infections and mycoses medicine.disease Endocrinology Estrogen Estrogen receptor alpha Original Article business |
| Zdroj: | Diabetes & Metabolism Journal Diabetes & Metabolism Journal, Vol 37, Iss 4, Pp 270-277 (2013) |
| ISSN: | 2233-6087 2233-6079 |
| DOI: | 10.4093/dmj.2013.37.4.270 |
| Popis: | Background Estrogen plays a fundamental role in the pathogenesis of type 2 diabetes mellitus (T2DM). Very few studies have shown the association between estrogen receptor α (ERα), PvuII and XbaI gene polymorphisms with T2DM in both men and women. We evaluated the hypothesis that PvuII and XbaI polymorphisms of ERα gene may be associated with T2DM in adult. Methods From spring of 2010 to the fall of 2011, a case-control study was performed at clinical centers of Jahrom University of Medical Sciences. We included 174 patients with T2DM including men and women and 174 age, sex, and body mass index frequency-matched health controls. We analyzed the PvuII and XbaI polymorphisms of ERα by using the polymerase chain reaction-based restriction fragment length polymorphism method. Results No significant differences between demographic characteristics of control and patients groups were observed. Allele frequencies of both PvuII and XbaI polymorphisms were significantly different between patients and control subjects (P=0.014 vs. P=0.002, respectively). When the group was separated into women and men, logistic regression analysis of genotype distribution of PvuII (pp vs. Pp+PP) in both sexes revealed that there was no significant association of PvuII genotype with men (odds ratio [OR], 1.67; confidence interval [CI], 0.86 to 3.28; P=0.89) and women (OR, 0.96; CI, 0.53 to 1.74; P=0.12). Conclusion PvuII and XbaI polymorphisms in ERα are related with T2DM in the inpatient population. |
| Databáze: | OpenAIRE |
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