Dietary syringic acid reduces fat mass in an ovariectomy-induced mouse model of obesity
| Autor: | Kazuko Iwamoto, Toshiyuki Suzuki, Nobuhisa Kawaguchi, Erika Yano, Tatsuya Moriyama, Yoshimi Homma, Maki Wada, Norifumi Shirasaka, Teruyoshi Tanaka |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Ovariectomy Estrogen receptor Type 2 diabetes Diet High-Fat chemistry.chemical_compound Mice Internal medicine Diabetes mellitus Gallic Acid Medicine Animals Humans Obesity Triglyceride Adiponectin business.industry Body Weight Obstetrics and Gynecology medicine.disease Endocrinology chemistry Diabetes Mellitus Type 2 Estrogen Ovariectomized rat Female business |
| Zdroj: | Menopause (New York, N.Y.). 28(12) |
| ISSN: | 1530-0374 |
| Popis: | OBJECTIVE Postmenopausal women are at increased risk of metabolic diseases such as obesity and diabetes. Therefore, the chemoprevention of postmenopausal changes in health via dietary supplements is important. Syringic acid (SA) is a phenolic compound present in the fruit of the assai palm, Euterpe oleracea, and in the mycelium of the shiitake mushroom, Lentinula edodes. This compound shows no affinity for estrogen receptors and may exert disease-preventive effects. Reportedly, dietary SA ameliorates high-fat diet-induced obesity in mice; however, its effects on estrogen deficiency-induced obesity are still unclear. Therefore, in this study, we investigated whether and how dietary SA affects these factors in ovariectomized (OVX) mice. METHODS Ten-week-old OVX mice were fed SA-containing diets (100 mg/kg body weight/d) for 12 weeks. Their body weights, food intake, and uterus weights as well as other parameters were measured and comparisons were made with mice in the control group. RESULTS Dietary SA did not affect the body weight, food intake, or uterus weight of OVX mice over the study period; however, the SA-fed group showed lower fat mass (ie, visceral, subcutaneous, and total fat) than the OVX-control group (11.1 ± 3.3 vs. 8.3 ± 2.4, P |
| Databáze: | OpenAIRE |
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