The Combination Effect of Ferulic Acid and Gemcitabine on Expression of Genes Related Apoptosis and Metastasis in PC-3 Prostate Cancer Cells
| Autor: | Yavuz Dodurga, Mücahit Seçme, Canan Eroğlu, Ercan Kurar, Hasibe Cingilli Vural, Ebru Avcı |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Volume: 77, Issue: 1 32-37 European Journal of Biology |
| ISSN: | 2618-6144 2602-2575 |
| Popis: | DOI:10.26650/EuroJBiol.2018.0003Objective: Prostate cancer is the secondmost common cause of cancer-related deaths in men. Nowadays, new treatmentapproaches have been tested for cancer therapy including natural compounds withlow toxicity. Ferulic acid (FA) is known as an abundant phenolic compound foundin various fruits and vegetables. As a potent antioxidant, the anticarcinogeniceffect of FA has been demonstrated in various cancer cell lines. The objectiveof this study was to investigate the combined effect of FA and gemcitabine onapoptosis and metastasis in PC-3 human prostate cancer cell lines. Materials and Methods: Cell viability wasdetermined using the XTT method after the cells were treated with gemcitabineor FA and gemcitabine. According to the results of cytotoxicity assays, PC-3cells were treated with DOI: 10.26650/EuroJBiol.2018.0003Objective: Prostate cancer is the second most common cause of cancer-related deaths in men. Nowadays, new treatment approaches have been tested for cancer therapy including natural compounds with low toxicity. Ferulic acid (FA) is known as an abundant phenolic compound found in various fruits and vegetables. As a potent antioxidant, the anticarcinogenic effect of FA has been demonstrated in various cancer cell lines. The objective of this study was to investigate the combined effect of FA and gemcitabine on apoptosis and metastasis in PC-3 human prostate cancer cell lines.Materials and Methods: Cell viability was determined using the XTT method after the cells were treated with gemcitabine or FA and gemcitabine. According to the results of cytotoxicity assays, PC-3 cells were treated with |
| Databáze: | OpenAIRE |
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