Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients
| Autor: | Birgit Nomeland Witczak, Thomas Schwartz, Ingjerd W. Manner, Ivar Sjaastad, Bård Waldum-Grevbo, Ingrid Os, Olav Øktedalen, Morten Baekken |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cardiac function curve medicine.medical_specialty CD4-CD8 Ratio Blood Pressure HIV Infections Viremia 030204 cardiovascular system & hematology Nocturnal 03 medical and health sciences 0302 clinical medicine Diastole Bayesian multivariate linear regression Internal medicine Internal Medicine medicine Humans Hiv infected patients Longitudinal Studies 030212 general & internal medicine business.industry Heart General Medicine Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease Circadian Rhythm Blood pressure Endocrinology Ambulatory Cardiology Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Blood Pressure. 26:332-340 |
| ISSN: | 1651-1999 0803-7051 |
| Popis: | Purpose: Non-dipping nocturnal blood pressure (BP) pattern has been reported prevalent among HIV-infected patients and is associated with adverse cardiovascular outcomes. The aims of this observational study were to identify predictors of nocturnal BP decline, and to explore whether diurnal BP profile is associated with alterations in cardiac structure and function.Materials and methods: A total of 108 treated HIV-infected patients with suppressed viremia underwent ambulatory BP measurement, 51 of these patients also underwent echocardiography.Results: Non-dipping nocturnal BP pattern was present in 51% of the patients. Decreased nocturnal decline in systolic BP (SBP) correlated with lower CD4 count (rsp = 0.21, p = 0.032) and lower CD4/CD8 ratio (rsp = 0.26, p = 0.008). In multivariate linear regression analyses, lower BMI (p = 0.015) and CD4/CD8 ratio |
| Databáze: | OpenAIRE |
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