Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration
| Autor: | Randall L. Kincaid, Melvin L. Billingsley |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Tau protein
Phosphatase Nerve Tissue Proteins tau Proteins Context (language use) Protein Serine-Threonine Kinases Microtubules Second Messenger Systems Biochemistry Dephosphorylation Alzheimer Disease Microtubule Phosphoprotein Phosphatases medicine Animals Humans Phosphorylation Molecular Biology Cells Cultured Cytoskeleton biology Kinase Cell Membrane Neurodegeneration Biological Transport Cell Biology medicine.disease Axons Rats Cell biology Nerve Degeneration biology.protein Protein Processing Post-Translational Research Article |
| Zdroj: | Biochemical Journal. 323:577-591 |
| ISSN: | 1470-8728 0264-6021 |
| DOI: | 10.1042/bj3230577 |
| Popis: | This review attempts to summarize what is known about tau phosphorylation in the context of both normal cellular function and dysfunction. However, conceptions of tau function continue to evolve, and it is likely that the regulation of tau distribution and metabolism is complex. The roles of microtubule-associated kinases and phosphatases have yet to be fully described, but may afford insight into how tau phosphorylation at the distal end of the axon regulates cytoskeletal–membrane interactions. Finally, lipid and glycosaminoglycan modification of tau structure affords yet more complexity for regulation and aggregation. Continued work will help to determine what is causal and what is coincidental in Alzheimer's disease, and may lead to identification of therapeutic targets for halting the progression of paired helical filament formation. |
| Databáze: | OpenAIRE |
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