5-HT3R Binding of lerisetron: an interdisciplinary approach to drug–Receptor interactions

Autor:	Harish S. Parihar, Marvin K. Schulte, Karen S Kirschbaum, Prasad R. Joshi, Asha Suryanarayanan, Padma Venkataraman, Chun Ma
Rok vydání:	2001
Předmět:	Agonist Lerisetron medicine.drug_class Stereochemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Partial agonist Structure-Activity Relationship chemistry.chemical_compound Piperidines Drug Discovery medicine Structure–activity relationship Binding site Molecular Biology Chemistry Organic Chemistry Ligand (biochemistry) Drug Design Receptors Serotonin Benzyl group Molecular Medicine Drug receptor Benzimidazoles Serotonin Antagonists Receptors Serotonin 5-HT3 medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 11:2133-2136
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(01)00417-6
Popis:	The design, synthesis, and use of lerisetron-based molecular probes to investigate the 5-HT 3 R binding site are described. A SAR study, which involved distance and electronic parameter modifications of lerisetron's N -benzyl group, resulted in the discovery of a partial agonist.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5615777a50453712c970d470f927e786 https://doi.org/10.1016/s0960-894x(01)00417-6 Zobrazit plný text záznamu Full Text from ScienceDirect