Closed-loop functional optogenetic stimulation
| Autor: | Hyungeun Song, Maurizio Diaz, Benjamin E. Maimon, Hugh M. Herr, Shriya Srinivasan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Computer science Science Movement General Physics and Astronomy Stimulation Mice Transgenic Optogenetics General Biochemistry Genetics and Molecular Biology Article Feedback 03 medical and health sciences Mice 0302 clinical medicine Neuromuscular stimulation Peripheral Nervous System Overshoot (signal) Functional electrical stimulation Animals lcsh:Science Muscle Skeletal Multidisciplinary General Chemistry Electric Stimulation Rats Inbred F344 Rats Controllability 030104 developmental biology Fascicle length lcsh:Q Neuroscience Closed loop 030217 neurology & neurosurgery Ankle Joint |
| Zdroj: | Nature Communications Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
| ISSN: | 2041-1723 |
| Popis: | Optogenetics has been used to orchestrate temporal- and tissue-specific control of neural tissues and offers a wealth of unique advantages for neuromuscular control. Here, we establish a closed-loop functional optogenetic stimulation (CL-FOS) system to control ankle joint position in murine models. Using the measurement of either joint angle or fascicle length as a feedback signal, we compare the controllability of CL-FOS to closed-loop functional electrical stimulation (CL-FES) and demonstrate significantly greater accuracy, lower rise times and lower overshoot percentages. We demonstrate orderly recruitment of motor units and reduced fatigue when performing cyclical movements with CL-FOS compared with CL-FES. We develop and investigate a 3-phase, photo-kinetic model to elucidate the underlying mechanisms for temporal variations in optogenetically activated neuromusculature during closed-loop control experiments. Methods and insights from this study lay the groundwork for the development of closed-loop optogenetic neuromuscular stimulation therapies and devices for peripheral limb control. Optogenetics is a promising alternative approach for restoration of neuromuscular function. Here the authors establish a closed-loop functional optogenetic stimulation for the control of limb joint angle in murine models, which demonstrates improved control and less fatigue than electrical stimulation systems. |
| Databáze: | OpenAIRE |
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