Antibiotic-associated complications following lower limb arthroplasty: a comparison of two prophylactic regimes
| Autor: | E. Bayley, S. Craxford, M. Needoff |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Joint replacement Arthroplasty Replacement Hip medicine.medical_treatment Floxacillin Surgical prophylaxis Postoperative Complications medicine Humans Orthopedics and Sports Medicine Antibiotic prophylaxis Arthroplasty Replacement Knee Enterocolitis Pseudomembranous Aged Retrospective Studies Aged 80 and over Cefuroxime Clostridioides difficile business.industry Retrospective cohort study Acute Kidney Injury Antibiotic Prophylaxis Middle Aged Arthroplasty Anti-Bacterial Agents Anesthesia Surgery Gentamicin Flucloxacillin Gentamicins business medicine.drug |
| Zdroj: | European Journal of Orthopaedic Surgery & Traumatology. 24:539-543 |
| ISSN: | 1432-1068 1633-8065 |
| DOI: | 10.1007/s00590-013-1348-1 |
| Popis: | As part of a wider drive to reduce Clostridium difficile rates (CDAD), our trust switched from cefuroxime to gentamicin and flucloxacillin prophylaxis for joint replacement surgery. Anecdotal evidence suggested that we were seeing an increased incidence of acute kidney injury (AKI) following elective total hip replacement (THR) and total knee replacement (TKR) since this change. The aim of this study was to compare rates of AKI and post-operative infection between the two antibiotic regimes. We carried out a single-centre retrospective cohort study comparing 200 patients (100 THR and 100 TKR) who received cefuroxime with another age and procedure-matched group who received gentamicin and flucloxacillin (gentamicin 3 mg/kg and 5 g flucloxacillin in total). We compared rates of AKI, haemofiltration, CDAD, surgical site infection (SSI) and return to theatre for infection (RTT). Gentamicin was associated with a significant increase in AKI (1 vs. 8 %, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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