Indium-Catalyzed Aromative Spiro Coupling of Quinones with Oxindoles for Highly Functionalized Xanthenes as Efficient Fluorophores
| Autor: | Sonaimuthu Mohandoss, Yong Rok Lee, SangGuan You, Sung Hong Kim, Won-Guen Yang, Mohammad Aslam, Palanisamy Subramanian |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Ionophores
Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry Quinones chemistry.chemical_element 010402 general chemistry Indium 01 natural sciences Biochemistry Combinatorial chemistry Catalysis Oxindoles 0104 chemical sciences Coupling (electronics) chemistry.chemical_compound Xanthenes Cyclization Oxindole Physical and Theoretical Chemistry Fluorescent Dyes |
| Zdroj: | Organic Letters. 23:1383-1387 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.1c00042 |
| Popis: | A convenient and an efficient protocol for the assembly of diverse xanthenes bearing a biologically interesting oxindole nucleus is developed by utilizing the In(III)-catalyzed spiro coupling of 1,4-benzoquinones or 1,4-naphthoquinones with oxindoles. This novel protocol proceeds via a cascade of double Michael additions and intramolecular cyclization. The synthesized compounds have potential use as fluorophores for the selective imaging of heavy metals in living cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|