Predictors and reproducibility of urinary organophosphate ester metabolite concentrations during pregnancy and associations with birth outcomes in an urban population
Autor: | Xiaobin Wang, Jessie P. Buckley, Irina Burd, Jordan R. Kuiper, Marsha Wills-Karp, Heather M. Stapleton |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Urban Population Health Toxicology and Mutagenesis Metabolite Physiology 010501 environmental sciences Organophosphate ester 01 natural sciences chemistry.chemical_compound Plasticizers Pregnancy Medicine Birth outcomes Insulin Generalized estimating equation Flame Retardants 0303 health sciences education.field_of_study lcsh:Public aspects of medicine Gestational age Esters Middle Aged Fetal Blood Organophosphates Maternal Exposure Cohort Gestational lcsh:Industrial medicine. Industrial hygiene Gestation Environmental Pollutants Female Adult Adolescent Offspring Population Young Adult 03 medical and health sciences lcsh:RC963-969 Adipokines Humans education 030304 developmental biology 0105 earth and related environmental sciences Predictors business.industry Research Infant Newborn Public Health Environmental and Occupational Health Reproducibility of Results lcsh:RA1-1270 medicine.disease Ponderal index chemistry Baltimore business Biomarkers |
Zdroj: | Environmental Health, Vol 19, Iss 1, Pp 1-15 (2020) Environmental Health |
Popis: | Background Organophosphate esters (OPEs) are synthetic chemicals used as flame retardants and plasticizers in a variety of goods. Despite ubiquitous human exposures and laboratory evidence that prenatal OPE exposures may disrupt offspring metabolism, perinatal studies of OPE health effects are limited. The objectives of this study were to: 1) Determine predictors and reproducibility of urinary OPE biomarker concentrations during pregnancy, and 2) Estimate the relation of prenatal OPE exposures with birth outcomes and cord blood adipokine and insulin concentrations. Methods We analyzed five OPE metabolites in urine samples collected at up to three visits during pregnancy from 90 women enrolled in the ORigins of Child Health And Resilience in Development (ORCHARD) pregnancy cohort in Baltimore, MD from 2017 to 2019. To quantify the variability of metabolite concentrations during pregnancy, we calculated intraclass correlation coefficients (ICCs) for each metabolite using mixed effects regression models. Using self-reported questionnaire data collected during gestation, we assessed possible sociodemographic and environmental/behavioral predictors of each OPE metabolite using generalized estimating equations to account for repeated exposure measures. We ascertained birth outcomes of 76 offspring from medical records, including weight-for-gestational age, length, ponderal index, and gestational age. In a subset of 37 infants, we measured cord blood concentrations of leptin, adiponectin, and insulin. To account for repeated exposure measures, we used linear structural equation models to assess the relations of standard deviation (SD) increases in prenatal OPE metabolite factor scores with continuous birth outcomes and cord blood biomarker concentrations. Results ICCs ranged from 0.09 for isopropylphenyl-phenyl phosphate (ip-PPP) to 0.59 for bis(1,3-dichloro-2-propyl) phosphate (BDCIPP). We observed little consistency in environmental or behavioral predictors of OPE exposures, although concentrations were generally lower for samples collected in the afternoon compared to morning and winter compared to other seasons. In adjusted analyses, a SD increase in BDCIPP concentration was associated with a 0.06 g/cm3 (95% CI: 0.00, 0.12) greater ponderal index. A SD increase in BDCIPP was associated with a 0.37 (95% CI: − 0.62, − 0.13) SD lower insulin concentration and 0.24 (95% CI: − 0.39, − 0.08) SD lower leptin concentration. Other OPEs were not associated with infant outcomes. Conclusions These findings suggest some OPEs may be metabolic disruptors warranting investigation in larger studies. |
Databáze: | OpenAIRE |
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