Predictors and reproducibility of urinary organophosphate ester metabolite concentrations during pregnancy and associations with birth outcomes in an urban population

Autor: Xiaobin Wang, Jessie P. Buckley, Irina Burd, Jordan R. Kuiper, Marsha Wills-Karp, Heather M. Stapleton
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Urban Population
Health
Toxicology and Mutagenesis

Metabolite
Physiology
010501 environmental sciences
Organophosphate ester
01 natural sciences
chemistry.chemical_compound
Plasticizers
Pregnancy
Medicine
Birth outcomes
Insulin
Generalized estimating equation
Flame Retardants
0303 health sciences
education.field_of_study
lcsh:Public aspects of medicine
Gestational age
Esters
Middle Aged
Fetal Blood
Organophosphates
Maternal Exposure
Cohort
Gestational
lcsh:Industrial medicine. Industrial hygiene
Gestation
Environmental Pollutants
Female
Adult
Adolescent
Offspring
Population
Young Adult
03 medical and health sciences
lcsh:RC963-969
Adipokines
Humans
education
030304 developmental biology
0105 earth and related environmental sciences
Predictors
business.industry
Research
Infant
Newborn

Public Health
Environmental and Occupational Health

Reproducibility of Results
lcsh:RA1-1270
medicine.disease
Ponderal index
chemistry
Baltimore
business
Biomarkers
Zdroj: Environmental Health, Vol 19, Iss 1, Pp 1-15 (2020)
Environmental Health
Popis: Background Organophosphate esters (OPEs) are synthetic chemicals used as flame retardants and plasticizers in a variety of goods. Despite ubiquitous human exposures and laboratory evidence that prenatal OPE exposures may disrupt offspring metabolism, perinatal studies of OPE health effects are limited. The objectives of this study were to: 1) Determine predictors and reproducibility of urinary OPE biomarker concentrations during pregnancy, and 2) Estimate the relation of prenatal OPE exposures with birth outcomes and cord blood adipokine and insulin concentrations. Methods We analyzed five OPE metabolites in urine samples collected at up to three visits during pregnancy from 90 women enrolled in the ORigins of Child Health And Resilience in Development (ORCHARD) pregnancy cohort in Baltimore, MD from 2017 to 2019. To quantify the variability of metabolite concentrations during pregnancy, we calculated intraclass correlation coefficients (ICCs) for each metabolite using mixed effects regression models. Using self-reported questionnaire data collected during gestation, we assessed possible sociodemographic and environmental/behavioral predictors of each OPE metabolite using generalized estimating equations to account for repeated exposure measures. We ascertained birth outcomes of 76 offspring from medical records, including weight-for-gestational age, length, ponderal index, and gestational age. In a subset of 37 infants, we measured cord blood concentrations of leptin, adiponectin, and insulin. To account for repeated exposure measures, we used linear structural equation models to assess the relations of standard deviation (SD) increases in prenatal OPE metabolite factor scores with continuous birth outcomes and cord blood biomarker concentrations. Results ICCs ranged from 0.09 for isopropylphenyl-phenyl phosphate (ip-PPP) to 0.59 for bis(1,3-dichloro-2-propyl) phosphate (BDCIPP). We observed little consistency in environmental or behavioral predictors of OPE exposures, although concentrations were generally lower for samples collected in the afternoon compared to morning and winter compared to other seasons. In adjusted analyses, a SD increase in BDCIPP concentration was associated with a 0.06 g/cm3 (95% CI: 0.00, 0.12) greater ponderal index. A SD increase in BDCIPP was associated with a 0.37 (95% CI: − 0.62, − 0.13) SD lower insulin concentration and 0.24 (95% CI: − 0.39, − 0.08) SD lower leptin concentration. Other OPEs were not associated with infant outcomes. Conclusions These findings suggest some OPEs may be metabolic disruptors warranting investigation in larger studies.
Databáze: OpenAIRE
Nepřihlášeným uživatelům se plný text nezobrazuje