Study of the Pathogen Inactivation Mechanism in Salt-Coated Filters
| Autor: | Sang-Moo Kang, Matthew Lawson, Ki-Hye Kim, Sumin Han, Fu-Shi Quan, Hae-Ji Kang, Noopur Bhatnagar, Ki-Back Chu, Hyo-Jick Choi, Yu-Jin Jung, Su-Hwa Lee, Euna Oh, Surjith Kumar Kumaran, Ilaria Rubino, Dong-Hun Lee |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Recrystallization (geology) Potassium Sodium Salt (chemistry) chemistry.chemical_element 030501 epidemiology Sodium Chloride Polypropylenes Potassium Chloride 03 medical and health sciences chemistry.chemical_compound Influenza A Virus H1N1 Subtype X-Ray Diffraction General Materials Science Respiratory Protective Devices 030304 developmental biology Air filter chemistry.chemical_classification Aerosols 0303 health sciences Chromatography Sulfates Masks Temperature Membranes Artificial Antimicrobial Potassium sulfate Kinetics Klebsiella pneumoniae Membrane chemistry Air Filters Powders 0305 other medical science Crystallization Filtration |
| Zdroj: | ACS applied materialsinterfaces. 13(14) |
| ISSN: | 1944-8252 |
| Popis: | As COVID-19 exemplifies, respiratory diseases transmitted through aerosols or droplets are global threats to public health, and respiratory protection measures are essential first lines of infection prevention and control. However, common face masks are single use and can cause cross-infection due to the accumulated infectious pathogens. We developed salt-based formulations to coat membrane fibers to fabricate antimicrobial filters. Here, we report a mechanistic study on salt-induced pathogen inactivation. The salt recrystallization following aerosol exposure was characterized over time on sodium chloride (NaCl), potassium sulfate (K2SO4), and potassium chloride (KCl) powders and coatings, which revealed that NaCl and KCl start to recrystallize within 5 min and K2SO4 within 15 min. The inactivation kinetics observed for the H1N1 influenza virus and Klebsiella pneumoniae matched the salt recrystallization well, which was identified as the main destabilizing mechanism. Additionally, the salt-coated filters were prepared with different methods (with and without a vacuum process), which led to salt coatings with different morphologies for diverse applications. Finally, the salt-coated filters caused a loss of pathogen viability independent of transmission mode (aerosols or droplets), against both DI water and artificial saliva suspensions. Overall, these findings increase our understanding of the salt-recrystallization-based technology to develop highly versatile antimicrobial filters. |
| Databáze: | OpenAIRE |
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