Bone pain at leukemia diagnosis and other risk factors for symptomatic osteonecrosis in children with acute lymphoblastic leukemia
| Autor: | Shai Izraeli, Naomi Litichever, Shlomit Barzilai-Birenboim, Galia Avrahami, Joanne Yacobovich, Nira Arad-Cohen, Sarah Elitzur, Yair Zalcberg, Gil Gilad |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Pain Thrombophilia Tertiary Care Centers Young Adult 03 medical and health sciences 0302 clinical medicine Immunophenotyping Risk Factors Antineoplastic Combined Chemotherapy Protocols Humans Medicine Israel Risk factor Child Adverse effect Bone pain business.industry Osteonecrosis Infant Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Leukemia Logistic Models Oncology Child Preschool 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Cohort Female medicine.symptom business Body mass index 030215 immunology |
| Zdroj: | Pediatric Blood & Cancer. 68 |
| ISSN: | 1545-5017 1545-5009 |
| DOI: | 10.1002/pbc.29033 |
| Popis: | Background Osteonecrosis is a major cause of acute and long-lasting complications of acute lymphoblastic leukemia (ALL) therapy in children. Our study aimed to evaluate the prevalence, characteristics, risk factors, and outcome of osteonecrosis in children with ALL. Procedure The cohort included 559 children aged 1-20 years diagnosed with ALL between 2003 and 2018 at two tertiary medical centers in Israel and enrolled in two consecutive protocols: ALL-IC BFM 2002 and AIEOP-BFM ALL 2009. Symptomatic osteonecrosis was prospectively captured as an adverse event. Results Osteonecrosis occurred in 51 patients (9.1%). Ninety-four percent of the events were graded as moderate or severe (grades 3-4, Ponte di Legno Toxicity Working Group classification) and multiple bone involvement was common. Full resolution of osteonecrosis was documented in only 16% of the children (median follow-up 4.2 years). Stepwise logistic regression identified five risk factors for osteonecrosis, with a high predictive value (AUC = 0.88): older ageat ALL diagnosis, high-risk ALL group, T-cell immunophenotype, female gender, and a novel risk factor: bone pain at the time of leukemia diagnosis. In addition, osteonecrosis was less common among children of Arab ethnicity. Thrombophilia and an elevated age-adjusted body mass index were not confirmed as risk factors for osteonecrosis. Conclusion Due to the low rates of osteonecrosis resolution and its debilitating long-term impact, the identification of patients at high risk for osteonecrosis is important for their inclusion in further studies evaluating potential therapeutic adjustments. |
| Databáze: | OpenAIRE |
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