The influence of pretreatment with PPI on Helicobacter pylori eradication
| Autor: | Kuang, Sheng, Xu, Jinkang, Chen, Miaomiao, Zhang, Yongliang, Shi, Fangzhen, Lu, Xirong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Helicobacter pylori
PPI Amoxicillin Proton Pump Inhibitors General Medicine Anti-Bacterial Agents Helicobacter Infections meta-analysis Treatment Outcome Clarithromycin Metronidazole eradication Humans Drug Therapy Combination Systematic Review and Meta-Analysis Randomized Controlled Trials as Topic Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Background: In this meta-analysis, we aimed to comprehensively investigate the impact of pretreatment with proton pump inhibitor (PPI) on Helicobacter pylori (H. pylori) eradication and provide novel inspiration to clinical practice. Methods: Relevant studies were selected through PubMed, Embase, and Cochrane Library from inception to March 2021. Two reviewers performed the selection independently. The primary outcome of the meta-analysis was the eradication rate. A modified Jadad scale was used to evaluate literature quality quantitatively. Results: Ten studies were included in this research. The results showed no significant difference between PPI pretreatment and standard treatment on eradication of H. pylori [relative risk (RR): 1.17, 95% confidence interval (95% CI): 0.0.73–1.88]. There was no significant difference between the PPI pretreatment group and the standard therapy group for conventional triple therapy, PPI and amoxicillin and clarithromycin (RR: 1.29, 95% CI: 0.60–2.77). Similar results were obtained in the therapy strategy of PPI and amoxicillin and metronidazole (RR: 3.01, 95% CI: 0.62–14.74). Interestingly, for the therapy regimen of PPI and clarithromycin and metronidazole, PPI pretreatment indicated superiority on H. pylori eradication rate (RR: 0.48, 95% CI: 0.23–0.97, P |
| Databáze: | OpenAIRE |
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