Clinical significance of positive anti‐neutrophil cytoplasmic antibodies without evidence of anti‐neutrophil cytoplasmic antibodies‐associated vasculitis

Autor: Gil Bornstein, Ilan Ben-Zvi, Nadav Furie, Chagai Grossman
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Myeloblastin
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Enzyme-Linked Immunosorbent Assay
urologic and male genital diseases
Gastroenterology
Antibodies
Antineutrophil Cytoplasmic
03 medical and health sciences
0302 clinical medicine
Rheumatology
Predictive Value of Tests
immune system diseases
Proteinase 3
Internal medicine
Humans
Medicine
Clinical significance
cardiovascular diseases
030212 general & internal medicine
Israel
skin and connective tissue diseases
Aged
Peroxidase
Retrospective Studies
030203 arthritis & rheumatology
biology
business.industry
Antibody titer
Reproducibility of Results
Middle Aged
medicine.disease
respiratory tract diseases
Titer
Myeloperoxidase
biology.protein
Female
Antibody
business
Vasculitis
Neutrophil cytoplasmic
Biomarkers
Zdroj: International Journal of Rheumatic Diseases. 22:940-945
ISSN: 1756-185X
1756-1841
DOI: 10.1111/1756-185x.13483
Popis: AIM Anti-neutrophil cytoplasmic antibodies (ANCA) have a role in the diagnostic workup of ANCA-associated vasculitis. However, the clinical significance of positive ANCA in the absence of vasculitis is yet to be determined. Therefore, we sought to investigate the clinical spectrum and rate of patients with a positive ANCA without evidence of vasculitis. METHODS Retrospective analysis of patients positive for cytoplasmic ANCA (C-ANCA) and proteinase 3 (PR3) or P-ANCA and myeloperoxidase (MPO) between 2007 and 2016 in the Chaim Sheba Medical Center, Israel. The proportion of patients who had no evidence of vasculitis among all patients with a positive C-ANCA/PR3 or P-ANCA/MPO was calculated according to tertiles of enzyme-linked immunosorbent assay (ELISA) antibody levels. RESULTS Among 113 patients who tested positive for C-ANCA/PR3 or P-ANCA/MPO, 68 (60.1%) had no evidence of vasculitis. ELISA antibody titers were significantly higher among patients with vasculitis than those without (6.2 vs 3.2, for C-ANCA/PR3 and 5.4 vs 2.6 for P-ANCA/MPO, P
Databáze: OpenAIRE
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