Aggressive Pituitary Macroadenoma Treated With Capecitabine and Temozolomide Chemotherapy Combination in a Patient With Nelson’s Syndrome: A Case Report
| Autor: | Irene Hernandez, J. Hernando, Oriol Mirallas, Elena Martínez-Sáez, Anas Chaachou, A. Garcia-Alvarez, Betina Biagetti, Francesca Filippi-Arriaga, Anton Aubanell, Jaume Capdevila |
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| Přispěvatelé: | Institut Català de la Salut, [Mirallas O, Garcia-Alvarez A, Hernando J, Capdevila J] Servei d’Oncologia Mèdica, Unitat de Tumors Gastrointestinals i Endocrins, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Filippi-Arriaga F] Servei de Farmacologia Clínica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Hernandez Hernandez I, Biagetti B] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Aubanell A] Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Chaachou A, Martínez-Saez E] Servei de Patologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Hipòfisi - Tumors - Tractament
Adenoma Male medicine.medical_specialty Side effect Endocrinology Diabetes and Metabolism medicine.medical_treatment Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores] Case Report Disease temozolomide aggressive pituitary tumors Adenoma - Tractament Other subheadings::Other subheadings::/drug therapy [Other subheadings] Quimioteràpia combinada Diseases of the endocrine glands. Clinical endocrinology Neoplasms::Neoplasms by Histologic Type::Neoplasms Glandular and Epithelial::Adenoma [DISEASES] Nelson Syndrome Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Pituitary Neoplasms::ACTH-Secreting Pituitary Adenoma::Nelson Syndrome [DISEASES] Capecitabine Endocrinology Therapeutics::Therapeutics::Drug Therapy::Antineoplastic Protocols::Therapeutics::Drug Therapy::Antineoplastic Combined Chemotherapy Protocols [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Antineoplastic Combined Chemotherapy Protocols Medicine Humans Neoplasm Invasiveness Pituitary Neoplasms neoplasias::neoplasias por tipo histológico::neoplasias glandulares y epiteliales::adenoma [ENFERMEDADES] Adverse effect Chemotherapy Temozolomide Nelson’s syndrome business.industry capecitabine Pituitary tumors Nelson's syndrome terapéutica::terapéutica::farmacoterapia::protocolos antineoplásicos::terapéutica::farmacoterapia::protocolos de quimioterapia antineoplásica combinada [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Middle Aged medicine.disease RC648-665 Surgery Tumor Burden Treatment Outcome neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias hipofisarias::adenoma hipofisario secretor de ACTH::síndrome de Nelson [ENFERMEDADES] Spain business medicine.drug |
| Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) Scientia |
| ISSN: | 1664-2392 |
| Popis: | Agressive pituitary tumors; Capecitabine; Temozolomide Tumores hipofisarios agresivos; Capecitabina; Temozolomida Tumors hipofisaris agressius; Capecitabina; Temozolomida Nelson’s syndrome is considered a severe side effect that can occur after a total bilateral adrenalectomy in patients with Cushing’s disease. It usually presents with clinical manifestations of an enlarging pituitary tumor including visual and cranial nerve alterations, and if not treated, can cause death through local brain compression or invasion. The first therapeutic option is surgery but in extreme cases of inaccessible or resistant aggressive pituitary tumors; the off-label use of chemotherapy with capecitabine and temozolomide can be considered. However, the use of this treatment is controversial due to adverse events, lack of complete response, and inability to predict results. We present the case of a 48-year-old man diagnosed with Nelson’s syndrome with prolonged partial response and significant clinical benefit to treatment with capecitabine and temozolomide. |
| Databáze: | OpenAIRE |
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