Optimization of a Y-graft design for improved hepatic flow distribution in the Fontan circulation
| Autor: | Weiguang Yang, Shawn C. Shadden, Alison L. Marsden, Jeffrey A. Feinstein, Irene E. Vignon-Clementel |
|---|---|
| Přispěvatelé: | Department of Mechanical and Aerospace Engineering [Univ California San Diego] (MAE - UC San Diego), University of California [San Diego] (UC San Diego), University of California (UC)-University of California (UC), Department of Pediatrics [Stanford], Stanford Medicine, Stanford University-Stanford University, Department of Bioengineering [Stanford], Stanford University, Mechanical, Materials, and Aerospace Engineering (IIT Armour), Illinois Institute of Technology (IIT), Numerical simulation of biological flows (REO), Laboratoire Jacques-Louis Lions (LJLL), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Inria Paris-Rocquencourt, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), American Heart Association Burroughs Wellcome Fund Career Award Leducq Foundation INRIA associated team, Department of Mechanical and Aerospace Engineering [La Jolla] (UCSD), University of California-University of California |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Optimal design
Y-graft blood flow simulation medicine.medical_specialty Vena Cava Superior Computer science Flow distribution Biomedical Engineering Hemodynamics Vena Cava Inferior 030204 cardiovascular system & hematology Fontan Procedure Inferior vena cava Models Biological [SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] 03 medical and health sciences 0302 clinical medicine Superior vena cava Physiology (medical) Internal medicine medicine Humans [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph] surgical design [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] Simulation Work (physics) Constrained optimization [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] medicine.anatomical_structure medicine.vein Liver Ventricle Regional Blood Flow hepatic flow distribution (HFD) 030220 oncology & carcinogenesis Cardiology [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC] optimization Algorithms Fontan |
| Zdroj: | Journal of Biomechanical Engineering Journal of Biomechanical Engineering, 2013, in press, 135 (1), pp.011002. ⟨10.1115/1.4023089⟩ Journal of Biomechanical Engineering, American Society of Mechanical Engineers, 2013, in press, 135 (1), pp.011002. ⟨10.1115/1.4023089⟩ |
| ISSN: | 0148-0731 1528-8951 |
| DOI: | 10.1115/1.4023089⟩ |
| Popis: | International audience; Single ventricle heart defects are among the most serious congenital heart diseases, and are uniformly fatal if left untreated. Typically, a three-staged surgical course, consisting of the Norwood, Glenn, and Fontan surgeries is performed, after which the superior vena cava (SVC) and inferior vena cava (IVC) are directly connected to the pulmonary arteries (PA). In an attempt to improve hemodynamic performance and hepatic flow dis- tribution (HFD) of Fontan patients, a novel Y-shaped graft has recently been proposed to replace the traditional tube-shaped extracardiac grafts. Previous studies have demon- strated that the Y-graft is a promising design with the potential to reduce energy loss and improve HFD. However these studies also found suboptimal Y-graft performance in some patient models. The goal of this work is to determine whether performance can be improved in these models through further design optimization. Geometric and hemody- namic factors that influence the HFD have not been sufficiently investigated in previous work, particularly for the Y-graft. In this work, we couple Lagrangian particle tracking to an optimal design framework to study the effects of boundary conditions and geometry on HFD. Specifically, we investigate the potential of using a Y-graft design with unequal branch diameters to improve hepatic distribution under a highly uneven RPA/LPA flow split. As expected, the resulting optimal Y-graft geometry largely depends on the pulmo- nary flow split for a particular patient. The unequal branch design is demonstrated to be unnecessary under most conditions, as it is possible to achieve the same or better per- formance with equal-sized branches. Two patient-specific examples show that optimization-derived Y-grafts effectively improve the HFD, compared to initial nonopti- mized designs using equal branch diameters. An instance of constrained optimization shows that energy efficiency slightly increases with increasing branch size for the Y-graft, but that a smaller branch size is preferred when a proximal anastomosis is needed to achieve optimal HFD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|