Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse, and pufferfish genomes
| Autor: | Jerzy Adamski, Chikara Kokubu, Heiko Peters, Rudi Balling, Thomas Werner, Josef-Karl Gerber, Fabio Santagati, Jürgen H. Blusch, Kenji Imai |
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| Rok vydání: | 2001 |
| Předmět: |
Transcription
Genetic Molecular Sequence Data Biology Genome Mice Exon Transcription (biology) Genetics Animals Humans Amino Acid Sequence Gene Zebrafish Genomic organization Homeodomain Proteins Comparative genomics Binding Sites Base Sequence Sequence Homology Amino Acid Fugu Promoter DNA-Binding Proteins stomatognathic diseases Evolutionary biology PAX9 Transcription Factor Transcription Factors |
| Zdroj: | Mammalian Genome. 12:232-237 |
| ISSN: | 1432-1777 0938-8990 |
| DOI: | 10.1007/s003350010267 |
| Popis: | As a first step towards the identification of cis-regulatory elements of Pax9 by means of comparative genomics, we have analyzed genome regions encompassing the Pax9 gene in three vertebrate species, humans, mice (Mus musculus), and the Japanese pufferfish (Fugu rubripes). We show the genomic organization of Pax9 and its physical association with Nkx2-9 conserved in the three species. We discuss about possible implications of the conserved synteny between Pax9 and Nkx2-9 in a context of vertebrate evolution. This report also includes the first description of the primary structures of Fugu Pax9 and Nkx2-9. Furthermore, we report the identification of a novel upstream exon and putative transcription start sites in mouse Pax9. Our results suggest that transcription of Pax9 may be initiated at two alternative start sites and driven by TATA-less promoters. |
| Databáze: | OpenAIRE |
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