The association of prostatic lipids with progression, racial disparity and discovery of biomarkers in prostate cancer
| Autor: | Yin-Yuan Mo, Hao Mei, Zhenbang Chen, Wanxin Peng, Jinghe Mao, Patrick B. Kyle, Xinchun Zhou, Timothy Craig Allen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Population Phospholipid urologic and male genital diseases Pathogenesis chemistry.chemical_compound Prostate cancer Lipidomics Caucasian Americans (CA) medicine Racial disparity Animal model Triglyceride (TG) education Pathological RC254-282 Original Research Prostate cancer (PCa) education.field_of_study business.industry African American (AA) Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Oncology chemistry Cancer research Cholesteryl ester Population study lipids (amino acids peptides and proteins) Cholesteryl esters (CE) business Biomarkers |
| Zdroj: | Translational Oncology, Vol 14, Iss 12, Pp 101218-(2021) Translational Oncology |
| ISSN: | 1936-5233 |
| Popis: | Highlights • This study performed lipid profiling on human PCa and BPT tissues matched with patient's age and race, pathological grades and clinical stages. • The human prostatic lipid profiles were widely associated with the pathogenesis, progression and racial disparity of PCa. • Neutral lipids had greater impact on pathogenesis, progression and racial disparity of PCa as compared to phospholipids. Cholesteryl ester is the only lipid class significantly higher in PCa than in BPT in all population and stratified AA and CA populations. • A panel of prostatic lipid parameters in each study population were identified as diagnostic and prognostic biomarkers with high sensitivity, specificity and accuracy simultaneously. • Lipid profiling on mouse prostatic tissue from mouse PCa model further confirmed the roles of prostatic lipids on the pathogenesis, progression and discovery of diagnostic and prognostic biomarkers of PCa. In addition, this animal model was excellent to investigate prognostic lipid biomarkers in differentiation of indolent from aggressive PCa. Background It remains under-investigated whether prostatic lipid profiles are associated with pathogenesis, progression, racial disparity, and discovery of biomarkers in prostate cancer (PCa). Methods The electrospray ionization-tandem mass spectrometry was applied to quantitate prostatic lipids in human and mouse PCa and non-cancer prostatic tissues. Biostatistics and bioinformatics were used to compare the concentrations of prostatic lipids at levels of total lipid, group, class and individual species between PCa and benign prostatic tissues, between races, and among pathological conditions of PCa. Results Prostatic concentrations of total lipids as well as neutral lipids were significantly higher in PCa than in benign prostatic tissues in all population and Caucasian American population, but not in African American population. The prostatic phospholipid were not statistically different between PCa and benign prostatic tissues in all study populations. Cholesteryl ester is the only lipid class significantly higher in PCa than in benign prostatic tissues in all study populations. A panel of prostatic lipid parameters in each study population was identified as diagnostic and prognostic biomarkers with >60% of sensitivity, specificity and accuracy simultaneously. Lipid profiling on mouse prostatic tissues further confirmed correlation of prostatic lipid profiles to the pathogenesis and progression of PCa. In addition, a few prostatic lipids in mouse can serve as prognostic biomarkers in differentiation of indolent from aggressive PCa. Conclusion The prostatic lipids are widely associated with the pathogenesis, progression and racial disparity of PCa. A panel of prostatic lipids can serve as diagnostic, prognostic and race-specific biomarkers for PCa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|