Oral ciramadol: a new analgesic for postoperative pain
| Autor: | Peggy S Hunt, C. Boyd Loadholt, H. David Reines, William Rambo |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Benzylamines Pentazocine Time Factors Adolescent Narcotic medicine.medical_treatment Analgesic Placebo Oral administration medicine Ciramadol Humans Pharmacology (medical) Amines Aged Pharmacology Chemotherapy Aspirin Analgesics Pain Postoperative business.industry Middle Aged Anesthesia business medicine.drug |
| Zdroj: | Journal of clinical pharmacology. 26(2) |
| ISSN: | 0091-2700 |
| Popis: | Ciramadol, a new synthetic narcotic agonist-antagonist analgesic, was compared in 30 and 60 mg doses with pentazocine 50 mg, aspirin 650 mg, and placebo in the treatment of 153 patients with postoperative pain. All drugs were administered between six and 72 hours after surgery. Analgesic efficacy was assessed for six hours after study drug administration using verbal pain intensity, analog pain intensity, and verbal pain relief scales. Significantly (P less than .05) higher analgesic efficacy scores were seen with ciramadol 30 mg than with pentazocine 50 mg and placebo at most of the evaluation points. Doses of ciramadol 30 mg were significantly (P less than .05) more effective than aspirin 650 mg at several time periods, and ciramadol 60 mg was better than pentazocine and placebo at several evaluation times. The 30-mg dose of ciramadol was generally more effective than the 60-mg dose. The mean six-hour cumulative sum of pain intensity difference scores, total pain relief scores, and sum of pain analog intensity difference scores showed that the best analgesic response occurred in the ciramadol 30 mg group, followed by the ciramadol 60 mg, aspirin 650 mg, pentazocine 50 mg, and placebo groups. Side effects were rare and mild. There were no medically important changes in vital signs in any treatment group. |
| Databáze: | OpenAIRE |
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