| Autor: |
Michael Thy, Saik Urien, Naim Bouazza, Frantz Foissac, Inès Gana, Emmanuelle Bille, Agathe Béranger, Julie Toubiana, Romain Berthaud, Fabrice Lesage, Sylvain Renolleau, Jean-Marc Tréluyer, Sihem Benaboud, Mehdi Oualha |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical pharmacokinetics. 61(11) |
| ISSN: |
1179-1926 |
| Popis: |
We aimed to develop a meropenem population pharmacokinetic model in critically ill children receiving continuous renal replacement therapy and simulate dosing regimens to optimize patient exposure.Meropenem plasma concentration was quantified by high-performance liquid chromatography. Meropenem pharmacokinetics was investigated using a non-linear mixed-effect modeling approach. Monte Carlo simulations were performed to compute the optimal scheme of administration, according to the target of a 100% inter-dose interval time in which concentration is one to four times above the minimum inhibitory concentration (100% fT1-4×MIC).A total of 27 patients with a median age of 4 [interquartile range 0-11] years, a median body weight of 16 [range 7-35] kg receiving continuous renal replacement therapy were included. Concentration-time courses were best described by a one-compartment model with first-order elimination. Body weight (BW) produced significant effects on volume of distribution (V) and BW and continuous renal replacement therapy effluent flow rate (QMeropenem exposure in critically ill children receiving continuous renal replacement therapy needs dosing adjustments to the minimum inhibitory concentration that take into account body weight and the continuous renal replacement therapy effluent flow rate. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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