Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia : A group comparative study
| Autor: | Tansim Akhter, Marita Larsson, Tord Naessen, Ulf Bondesson, Gerhard Wikström, Mikael Hedeland |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Mean arterial pressure medicine.medical_specialty Carotid Artery Common Common carotid artery intima/media thickness ratio Cardiovascular risk factors High frequency ultrasound Reproduktionsmedicin och gynekologi Arginine Dimethylarginines Preeclampsia 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Risk Factors Internal medicine medicine.artery Obstetrics Gynecology and Reproductive Medicine medicine Humans 030212 general & internal medicine Common carotid artery Subclinical atherosclerosis Risk factor 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Gestational age medicine.disease Cardiovascular disease Reproductive Medicine Cardiovascular Diseases Heart Disease Risk Factors Cardiology Female Pregnant Women Ultrasonography business |
| Popis: | Objectives: Asymmetric- and symmetric dimethylarginines (ADMA, SDMA) are elevated in cardiovascular disease (CVD). Preeclampsia is a pregnancy-specific syndrome and is an independent risk factor for subsequent CVD. Aims were to investigate whether ADMA, SDMA levels and L-arginine/ADMA and I.arginine/SDMA ratios during pregnancy and their changes from pregnancy to postpartum are associated to arterial wall layer dimensions and cardiovascular risk factors in women with and without preeclampsia. Study design: Dimethylarginines were analyzed by LC-MS, and the common-carotid-artery (CCA) intima and media thicknesses were estimated using 22-MHz non-invasive ultrasonography in women with preeclampsia (cases = 48) and normal pregnancies (controls = 58) in similar gestational age, with reassessment one-year postpartum. A thick intima, thin media and high intima/media ratio (I/M) indicates a less healthy arterial wall. Results: The median age of cases and controls was 30 years. During pregnancy, women with preeclampsia had higher plasma ADMA, SDMA and lower t-arginine/ADMA and L-arginine/SDMA (all p |
| Databáze: | OpenAIRE |
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