Barium exposure increases the risk of congenital heart defects occurrence in offspring
| Autor: | Yixiong Guo, Nana Li, Jun Zhu, Zhen Liu, Ming Chen, Jiaxiang Yang, Ping Yu, Ying Deng, Nannan Zhang, Xiaoxian Tian |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Heart Defects Congenital China medicine.medical_specialty Offspring Placenta chemistry.chemical_element 030204 cardiovascular system & hematology 010501 environmental sciences Toxicology Logistic regression 01 natural sciences Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Prenatal Diagnosis Internal medicine medicine Humans 0105 earth and related environmental sciences Fetus Dose-Response Relationship Drug business.industry Obstetrics Heart Septal Defects Infant Newborn Case-control study Barium General Medicine Odds ratio medicine.disease Confidence interval Endocrinology chemistry Maternal Exposure Case-Control Studies Prenatal Exposure Delayed Effects Female business Hair |
| Zdroj: | Clinical Toxicology. 56:132-139 |
| ISSN: | 1556-9519 1556-3650 |
| DOI: | 10.1080/15563650.2017.1343479 |
| Popis: | Several studies have investigated the association between heavy metal exposure and congenital heart defects (CHDs). However, there are limited data regarding the relationship between barium exposure and the occurrence of CHDs. The objective of this study was to analyze the association between barium exposure in mothers and the risk of CHD in offspring.We developed a case-control study with 399 cases and 490 controls with normal live births in China. The concentrations of barium in hair of pregnant woman and fetal placenta were measured. We used a logistic regression analysis to explore the association between barium exposure and the risk of CHD.Logistic regression analysis indicated that the median concentration of barium in maternal hair in the CHD group was 4.180 ng/mg (adjusted odds ratio [aOR], 1.230; 95% confidence interval [CI], 1.146-1.321; p .001), which was significantly higher than that in the control group (2.740 ng/mg). Furthermore, the median concentration of barium in fetal placental tissue in the CHD group was 0.617 ng/mg, while that in the control group was 0.447 ng/mg (aOR, 1.392; 95% CI, 1.074-1.659; p = .003). Significant differences in the concentration of barium in hair were also found between the different CHD subtypes and the controls. These differences were found in cases with septal defects (p .001), conotruncal defects (p .001), right ventricular outflow track obstruction (p .001), left ventricular outflow track obstruction (p .001), and anomalous pulmonary venous return (p = .010). Significantly different barium concentrations in fetal tissue were only found in cases with septal defects (p = .010).Maternal barium exposure was dose-dependently related to the risk of CHD in the offspring. Our findings suggest that the occurrence of some subtypes of CHD is associated with barium exposure. |
| Databáze: | OpenAIRE |
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